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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Coronary Atherosclerosis by Modified American Heart Association Classification of Atherosclerosis-An Autopsy Study
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Study of Coronary Atherosclerosis by Modified American Heart Association Classification of Atherosclerosis-An Autopsy Study

机译：美国心脏协会动脉粥样硬化分类修正研究对冠状动脉粥样硬化的研究

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Background: The study was designed to assess the atherosclerotic lesions in coronary arteries in cases subjected to autopsy to grade by applying Modified American Heart Association (AHA) classification, evaluate the atheromatous & vulnerable plaques to find out the to age and sex related prevalence of atherosclerosis in the semi-urban & urban population of Jamnagar, a district in Western India.Material & Methods: Autopsy was conducted on 264 cases whose age ranged from 8-79 years, by the conventional technique; heart was removed & dissected along the direction of blood flow. Microscopic assessment of the three main coronary arteries was done.Result: According to Modified AHA classification of atherosclerosis, maximum number of cases were in the 40-49 years age group. Intimal xanthoma was the most common type in all three coronary arteries. The number of males was 168(64%) and females was 96(36%). 59% males & 52% female were affected from atherosclerosis. An intermediate lesion was noted commonly in young individuals (10-39 years) and older individuals (40-79 years) were 46% & 41% respectively. Pathological Intimal thickening was more common in left anterior descending coronary artery compared to others. Thin fibrous cap atheroma was more common in Left circumflex artery than compared to Left anterior descending artery & Right coronary artery.Conclusion: The study highlights the impact of atherosclerotic lesions in the population of Jamnagar, a district in Gujarat state of Western India. The increased amount of intermediate atherosclerotic lesions found in the young population gives an indication that anti-atherogenic preventive measures and drastic dietary & life style modification need to be implemented in young individuals, this will help to prevent coronary artery disease from causing premature death that lead to huge financial burden on the economy and health sector of India.
机译：背景：本研究旨在通过应用美国心脏协会（AHA）分类来评估接受尸检分级的冠状动脉粥样硬化病变，评估动脉粥样硬化和易损斑块，以发现与年龄和性别相关的动脉粥样硬化患病率材料与方法：采用传统技术对264例年龄在8至79岁之间的病例进行尸检。沿血流方向取出并解剖心脏。结果：根据改良的AHA动脉粥样硬化分类，最大病例数在40-49岁年龄段。内膜黄瘤是所有三个冠状动脉中最常见的类型。男性人数168（64％），女性人数96（36％）。 59％的男性和52％的女性患有动脉粥样硬化。通常在年轻个体（10-39岁）和老年人（40-79岁）中分别发现中度病变，分别为46％和41％。病理性内膜增厚较其他冠状动脉左前降支更常见。相比于左前降支动脉和右冠状动脉，稀薄的纤维帽动脉粥样硬化更常见于左旋支和右冠状动脉。结论：该研究强调了动脉粥样硬化病变对印度西部古吉拉特邦贾姆纳加尔地区的影响。在年轻人中发现的中间动脉粥样硬化病变数量增加，表明年轻人中需要实施抗动脉粥样硬化的预防措施以及饮食和生活方式的急剧改变，这将有助于防止冠状动脉疾病导致过早死亡，从而导致给印度经济和卫生部门带来沉重的财务负担。

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