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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Intrathecal Dexmedetomidine with Buprenorphine as Adjuvant to Bupivacaine in Spinal Asnaesthesia
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Comparison of Intrathecal Dexmedetomidine with Buprenorphine as Adjuvant to Bupivacaine in Spinal Asnaesthesia

机译：鞘内注射右美托咪定与丁丙诺啡作为布比卡因佐剂在脊髓麻醉中的比较

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Background: The supplementation of local anaesthetics with adjuvants to improve the efficacy of subarachnoid block has been recognised since long. The most preferred drug has been opioids, but newer drugs like dexmedetomidine has also been introduced and investigated as an effective adjuvant.Aim: This study was conducted to evaluate and compare the characteristics of subarachnoid blockade, hemodynamic stability and adverse effects of intrathecal buprenorphine and intrathecal dexmedetomidine as an adjuvant to 0.5% hyperbaric bupivacaine for lower abdominal surgeries.Materials and Methods: The present study included 60 patients aged between 18-60 years classified as ASA-PS I/II scheduled for elective lower abdominal surgeries. The patients were randomly allotted to two groups to receive intrathecal 3ml of 0.5% bupivacine with 60μg of buprenorphine (Group B; n=30) or 3ml of 0.5% bupivacaine with 5μg of dexmedetomidine (Group D; n= 30). The onset time to peak sensory level, motor block, sedation, Haemodynamic variables, duration of motor block, analgesia and any adverse effects were noted.Results: There was no significant difference between groups regarding demographic characteristics and type of surgery. The motor, sensory blockade and time of rescue analgesia were significantly prolonged in Group D compared to Group B. The sedation level was higher in Group D compared to Group B. There was no significant difference in haemodynamic variables although Group B had lower heart rate than Group D.Conclusion: Intrathecal dexmedetomidine when compared to intrathecal buprenorphine causes prolonged anaesthesia and analgesia with reduced need for sedation and rescue analgesics.
机译：背景：长期以来，人们已经认识到在局部麻醉药中添加佐剂以改善蛛网膜下腔阻滞的疗效。最优选的药物是阿片类药物，但还引入了新型药物如右美托咪定作为有效佐剂并进行了研究。目的：进行这项研究以评估和比较蛛网膜下腔阻滞剂的特征，血液动力学稳定性以及鞘内丁丙诺啡和鞘内注射的不良反应右美托咪定作为0.5％高压布比卡因用于下腹部手术的佐剂。材料与方法：本研究包括60例年龄在18-60岁之间的患者，被分类为ASA-PS I / II，计划进行择期下腹部手术。将患者随机分为两组，分别接受鞘内注射3ml 0.5％布比卡因和60μg丁丙诺啡（B组; n = 30）或3ml 0.5％布比卡因与5μg右美托咪定（D组; n = 30）。注意到达到峰值感觉水平，运动阻滞，镇静，血流动力学变量，运动阻滞持续时间，镇痛和任何不良反应的开始时间。结果：两组在人口统计学特征和手术类型方面无显着差异。与B组相比，D组的运动，感觉阻滞和抢救性镇痛时间明显延长。D组的镇静水平高于B组。虽然B组的心率低于B组，但血流动力学变量无明显差异。 D组结论：与鞘内丁丙诺啡相比，鞘内注射右美托咪定可导致麻醉和镇痛时间延长，镇静和急救镇痛药的需求减少。

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