...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Prevalence of Osteoarthritis of Knee Among Elderly Persons in Urban Slums Using American College of Rheumatology (ACR) Criteria
【24h】

Prevalence of Osteoarthritis of Knee Among Elderly Persons in Urban Slums Using American College of Rheumatology (ACR) Criteria

机译：使用美国风湿病学会（ACR）标准在城市贫民窟中老年人的膝骨关节炎患病率

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Over the past several decades, the use of drug therapy in COPD has expanded, and provides an optimistic picture. Methyixanthines are used freely in COPD. Of them, Theophylline is an age old bronchodilator and anti-inflammatory agent while Acebrophylline is a newer one. Both are used as add on therapy in management of stable COPD patients on LAMA (long acting muscarinic antagonists like Tiotropium) in present day respiratory practice. This study was designed to compare the efficacy as well as tolerability/side-effects of these two drugs at recommended doses.Materials and Methods: An open randomized comparative longitudinal study was conducted on 40 moderate degree COPD patients over a period of one year. The patients were randomized into Group-1:receiving Acebrophylline 100mg twice daily and Group-2: receiving sustained release (SR) Theophylline 300mg once daily orally, in addition to 18μgm Tiotropium inhalation per day through metered dose inhaler. Spirometric variables, symptomatic benefit and adverse effects were recorded on three visits (day ?0?, ?21? and ?42?). All the data were analyzed by SPSS version 17.Results: A comparable clinical improvement of symptoms score and spirometric parameters with both the drugs has been observed (p-value>0.05). Amount of sputum, frequency of use of reliever medication and dyspnoea showed improvement with both the drugs but cardiovascular side effects are less with Acebrophylline.Conclusion: This study reaffirms the rationale of use of Methylxanthines as add on therapy with LAMA in COPD management and cardiac safety level with Acebrophylline was considerable.
机译：简介：在过去的几十年中，药物疗法在COPD中的使用有所扩展，并提供了乐观的前景。甲氧黄嘌呤可在COPD中免费使用。其中，茶碱是一种古老的支气管扩张剂和抗炎药，而醋乙茶碱是一种较新的药物。在当今的呼吸实践中，这两种药物都可作为治疗LAMA的稳定COPD患者（长效毒蕈碱拮抗剂，如噻托铵）的辅助疗法。本研究旨在比较推荐剂量下这两种药物的疗效以及耐受性/副作用。材料与方法：一项开放随机比较纵向研究是对40名中度COPD患者进行的，为期一年。除每天通过计量吸入器吸入18μgm噻托溴铵外，将患者随机分为1组：每天两次接受醋氨茶碱100mg和2组：每天一次接受持续释放（SR）茶碱300mg。在3次就诊（第0天，第21天和第42天）记录肺活量变量，症状益处和不良反应。所有数据均通过SPSS 17版进行了分析。结果：观察到两种药物在症状评分和肺活量参数方面的可比临床改善（p值> 0.05）。痰的量，缓解药物的使用频率和呼吸困难均显示两种药物都有改善，但醋氨茶碱的心血管副作用较少。结论：本研究重申了将甲氧黄嘌呤与LAMA联合用于COPD管理和心脏安全性治疗的基本原理乙酰溴茶碱的水平相当高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号