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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Bromocriptine, a Dopamine (D2) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub?Therapeutic Doses to Ameliorate Hyperglycaemia
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Bromocriptine, a Dopamine (D2) Receptor Agonist, Used Alone and in Combination with Glipizide in Sub?Therapeutic Doses to Ameliorate Hyperglycaemia

机译：溴隐亭，一种多巴胺（D2）受体激动剂，单独使用或与格列吡嗪组合用于亚治疗剂量，可改善高血糖症

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Introduction: Bromocriptine, an ergot derivative, is an agonist at the dopamine 2 receptor and a sympatholytic. It is a well established drug in Parkinsonism, hyperprolactinaemia and acromegaly and it has various other clinical indications like induction of ovulation in female infertility. Bromocriptine has been evaluated in alloxan induced diabetic rats for its anti-hyperglycaemic effect with and without simultaneous use of glipizide.Methods: Diabetes was induced in albino rats by giving a single subcutaneous injection of alloxan in a dose of 150 mg/kg body weight. After 72 hours of giving alloxan injection, depending upon their blood glucose levels (350mg/dl and above), the rats were included into the study and they were divided into four groups, each comprising of 6 rats (n=24): Group 1 which was taken as control was given distilled water. Group 2 was treated with glipizide, a standard drug. Group 3 was treated with the test drug, bromocriptine and Group 4 was treated with sub therapeutic doses of test and standard drugs. The drugs were given to the diabetic rats once daily by oral route for 30 consecutive days, in order to assess their effects in terms of reduction in blood glucose levels. Blood glucose was estimated on 0th, 10th, 20th, and 30th days of the study at fixed time intervals.Results and Conclusion: Bromocriptine, which was used alone, lowered the blood glucose levels appreciably; whereas the concomitant administration of bromocriptine and glipizide in sub therapeutic doses produced a much more appreciable reduction. The results which were obtained in the group which received simultaneous administration of test and standard drugs in sub therapeutic doses were comparable to those of the group which received reference drug, glipizide. Hence, it can be concluded that bromocriptine may serve as a valuable adjunct to available anti-diabetic medication.
机译：简介：溴隐亭是麦角的衍生物，是多巴胺2受体的激动剂，具有交感作用。它是帕金森氏症，高泌乳素血症和肢端肥大症的公认药物，并且具有多种其他临床适应症，例如在女性不育症中诱导排卵。方法：在白化病大鼠中，通过皮下注射剂量为150 mg / kg体重的四氧嘧啶单次皮下注射，可在四氧嘧啶诱导的糖尿病大鼠中评估溴隐亭的降血糖作用。给予四氧嘧啶注射72小时后，根据其血糖水平（350mg / dl及以上），将大鼠纳入研究，将其分为四组，每组包括6只大鼠（n = 24）：第一组将其作为对照，给其蒸馏水。第2组用格列吡嗪（一种标准药物）治疗。第3组用受试药物溴隐亭治疗，第4组用亚治疗剂量的受试药物和标准药物治疗。为了评估其在降低血糖水平方面的作用，每天口服药物连续30天给糖尿病大鼠一次。在研究的第0、10、20和30天以固定的时间间隔估算血糖。结果与结论：溴隐亭单独使用可显着降低血糖水平。而溴隐亭和格列吡嗪以亚治疗剂量的同时给药产生了明显得多的降低。同时接受亚治疗剂量的试验药物和标准药物的组的结果与接受参考药物格列吡嗪的组的结果相当。因此，可以得出结论，溴隐亭可以作为可用的抗糖尿病药物的有价值的辅助手段。

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