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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study on Neuromuscular BlockadeAction of Verapamil in Albino Rats
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Study on Neuromuscular BlockadeAction of Verapamil in Albino Rats

机译：维拉帕米对白化病大鼠神经肌肉阻滞作用的研究

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Background:Calcium Channel Blockers (CCBs) are now widely employed in the treatment of cardiovascular diseases and peri operative hypertension. It has been reported that calcium channel blockers inhibit neuromuscular transmission. They have been shown to increase the neuromuscular blockade produced by neuromuscular blocking agents in in-vitro muscle nerve preparations. The present study is undertaken to demonstrate the effect of calcium channel blocker, verapamil on neuromuscular transmission in albino rats.Objectives:To study the neuromuscular blockade action of verapamil in albino rats.Methods:Twenty four albino rats of either sex weigh 150- 250gms are selected and are randomly divided into 4 equal groups. The experimental rats are divided into four groups of 6 rats each and they are given the following treatment. Group 1(Control) - Normal saline (1ml/ kg), Group 2 (Standard) - Pancuronium (0.04 mg/kg) Group 3-Verapamil (2.5mg/kg), Group 4-given Verapamil (10mg/kg). The time of onset of hind limb paralysis and total duration of recovery are noted using inclined screen method.Results:Analysis of the results of group 3 that was received 2.5mg/kg of Verapamil, there was no onset of paralysis, in group 4 that received injection Verapamil 10mg/kg, showed neuromuscular blockade activity. The mean onset of hind limb paralysis was delayed compared to standard group and the mean duration of hind limb paralysis was shorter than standard group. It was statistically significant (P=0.05).Interpretation and conclusion:It is generally held that external calcium is not necessary for the contraction of mammalian skeletal muscle, the demonstration of inward calcium currents that can be abolished by CCBs in these muscles prompted to re-examine the effect of Verapamil on the neuromuscular transmission. The present study allows us to determine the neuromuscular blockade activity of Verapamil
机译：背景：钙通道阻滞剂（CCBs）现在广泛用于治疗心血管疾病和围手术期高血压。据报道，钙通道阻滞剂抑制神经肌肉传递。已显示它们会增加体外肌肉神经制剂中神经肌肉阻滞剂产生的神经肌肉阻滞作用。本研究旨在证明钙通道阻滞剂维拉帕米对白化病大鼠神经肌肉传递的作用。目的：研究维拉帕米对白化病大鼠的神经肌肉阻断作用。方法：二十四只体重为150-250gms的白化病大鼠选择并随机分为4个相等的组。实验大鼠分为四组，每组六只，并给予以下治疗。第1组（对照组）-生理盐水（1ml / kg），第2组（标准）-潘库溴铵（0.04 mg / kg）第3组维拉帕米（2.5mg / kg），第4组给予维拉帕米（10mg / kg）。结果：采用2.5mg / kg的维拉帕米治疗后，对第3组的结果进行了分析，第3组没有出现麻痹的发生，第4组表明了后肢麻痹的发作时间和恢复的总时间。接受维拉帕米注射10mg / kg，显示神经肌肉阻滞活性。与标准组相比，后肢瘫痪的平均发作时间有所延迟，而后肢瘫痪的平均持续时间则短于标准组。具有统计学意义（P = 0.05）。解释和结论：通常认为，外部钙对于哺乳动物骨骼肌的收缩不是必需的，CCB可以消除这些肌肉中的内向钙流的提示促使其重新形成。 -检查维拉帕米对神经肌肉传递的影响。本研究使我们能够确定维拉帕米的神经肌肉阻滞活性

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