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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis
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Quantification of Plasma Fibrinogen Degradation Products in Areca Nut Chewers with and without Oral Submucous Fibrosis

机译：有和没有口腔粘膜下纤维化的槟榔咀嚼血浆血浆纤维蛋白原降解产物的定量

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Introduction: Fibrinogen degradation products (FDPs) are the products that are released from fibrin/fibrinogen. Recently, it has been observed that these FDPs have been identified in the plasma of OSMF patients. Areca nut being the major aetiological agent for OSMF may play a role in the increased plasma levels of FDPs in OSMF.Aim: The aim of this study was to quantify the plasma FDPs levels in the individuals with the habit of areca nut chewing with and without OSMF.Materials and Methods: Total of 95 subjects were included,35 subjects with the habit of areca nut chewing with OSMF, 30 with the habit of areca nut chewing without OSMF, 30 without any habit of areca nut chewing without OSMF (control group). Five ml of venous blood was withdrawn from all the subjects and plasma FDP levels were estimated.Results: Plasma FDPs were detected in all the subjects of OSMF but could not be detected in other two groups. As the clinical grades of OSMF increased, levels of plasma FDPs also increased.Conclusion: When plasma FDP increases, fibrin deposition also increases. This strengthens the finding that these FDPs may be an early indicator of the OSMF.
机译：简介：纤维蛋白原降解产物（FDPs）是从纤维蛋白/纤维蛋白原释放的产物。最近，已经观察到在OSMF患者的血浆中已经鉴定出这些FDP。槟榔是OSMF的主要病因，可能与OSMF中血浆FDP的升高有关。目的：本研究的目的是量化有和没有槟榔咀嚼习惯的个体的血浆FDP水平。材料和方法：共纳入95名受试者，其中35名有OSMF的槟榔咀嚼习惯的受试者，30名无OSMF的槟榔咀嚼习惯的受试者，30名没有OSMF的无槟榔咀嚼习惯的受试者（对照组） 。从所有受试者中抽取5毫升静脉血，并估计血浆FDP水平。结果：在所有OSMF受试者中均检测到血浆FDP，但在其他两组中均未检测到。随着OSMF的临床等级的升高，血浆FDP的水平也随之升高。结论：血浆FDP升高时，纤维蛋白沉积也增加。这加强了以下发现：这些FDP可能是OSMF的早期指标。

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