Background: Reference data on serum prolactin levels based on a representative Indian sample are still lacking. The western normative laboratory values used for clinical diagnosis may not be applicable to Indian population. The objective of the study was to measure the serum prolactin levels in healthy Indian male and female in order to establish reference interval and to compare with the available reference intervals. It is a cross- sectional study done in West Bengal, India.Materials and Methods: Based on the history, clinical examination and laboratory investigations, serum prolactin levels of 1316 apparently healthy subjects were estimated by microplate immunoenzymometric assay using pooled serum. Statistical analysis was performed using SPSS software.Results: The serum prolactin levels for all ages were 10.7 ± 3 ng/ml in healthy male and 11.6 ± 2.8 ng/ml in healthy female. Decade-wise analysis of serum prolactin level in female showed a steady increase from 20-29 years to advancing decades until 4th decade and thereafter declines steadily although it was not same for male.Conclusion: Our study will help each laboratory to formulate their own reference interval for prolactin. As of now they were dependent either on the values written on the kit-literature supplied by the reagent manufacturing company or the reference intervals of foreign population.
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机译：背景：仍然缺乏基于代表性印度样本的血清催乳素水平的参考数据。用于临床诊断的西方标准实验室值可能不适用于印度人口。该研究的目的是测量健康的印度男性和女性的血清催乳素水平，以建立参考区间并与可用的参考区间进行比较。这是在印度西孟加拉邦进行的一项横断面研究。材料与方法：根据历史，临床检查和实验室研究，通过微孔板免疫酶测定法，使用合并的血清评估了1316名健康受试者的血清催乳素水平。使用SPSS软件进行统计分析。结果：健康男性的所有年龄血清催乳素水平为10.7±3 ng / ml，健康女性为11.6±2.8 ng / ml。对女性血清催乳素水平的十年分析显示，从20-29岁到前进的几十年一直稳定增长到第四十年，此后稳步下降，尽管对于男性而言并不相同。结论：我们的研究将帮助每个实验室制定自己的参考标准催乳的间隔。到目前为止，它们取决于试剂制造公司提供的试剂盒文献上写的值或外国人口的参考间隔。
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