...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Alpha-1 Antitrypsin, a Diagnostic and Prognostic Marker of Vernal Keratoconjunctivitis
【24h】

Alpha-1 Antitrypsin, a Diagnostic and Prognostic Marker of Vernal Keratoconjunctivitis

机译：Alpha-1抗胰蛋白酶，春季角膜结膜炎的诊断和预后标记

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction:A major chunk of ocular allergies in humans involve the conjunctiva, of which Vernal Keratoconjunctivitis (VKC) appears to be more common. VKC, a chronic allergic conjunctivitis, frequently affects young males and is characterized by intense inflammation of the limbal and/or tarsal conjunctiva. The etiology and immuno- pathogenesis of VKC still remain unclear.Alpha-1 antitrypsin (AAT), a member of serine proteinase inhibitor (SERPIN) superfamily, is an acute phase protein whose concentration in blood increases in response to inflammation. AAT deficiency is one of the many factors that may be involved in several abnormalities such as liver disease, emphysema, inflammatory joint diseases and inflammatory eye diseases. In the present study, the role played by this protein in VKC was analyzed in a selective case/control study to assess its diagnostic and prognostic value.Materials and Methods:The case control study included 50 patients of VKC reporting to Ophthalmology out patient department (OPD). Age and sex matched 40 healthy subjects served as control. Serum AAT level of both the cases and controls were evaluated and compared. Moreover the serum AAT levels of the patients at presentation were compared with their serum AAT level after three weeks post treatment.Result:Levels of AAT in the serum of VKC patients at presentation (2.80 ± 0.42 mg/ml) were significantly higher as compared to controls (2.31 ± 0.21 mg/ml) whereas no significant difference was observed between the serum level of post treatment VKC patients (2.48 ± 0.26 mg/ml) and controls.Conclusion:AAT is a potent acute phase protein whose concentration rises significantly in VKC, irrespective of the age and sex of the patient. Moreover, the serum level of AAT declined significantly post treatment; therefore it might be used as a prognostic marker.
机译：简介：人类的大部分眼部过敏都涉及结膜，其中春季角膜结膜炎（VKC）似乎更为常见。 VKC是一种慢性过敏性结膜炎，经常感染年轻男性，其特征在于角膜缘和/或睑板结膜强烈炎症。 VKC的病因学和免疫机制尚不清楚。丝氨酸蛋白酶抑制剂（SERPIN）超家族成员Alpha-1抗胰蛋白酶（AAT）是一种急性期蛋白，其血液中的浓度会随着炎症反应而增加。 AAT缺乏是可能与多种异常有关的众多因素之一，例如肝脏疾病，肺气肿，炎症性关节疾病和炎症性眼病。在本研究中，通过选择性病例/对照研究分析了该蛋白在VKC中的作用，以评估其诊断和预后价值。材料和方法：病例对照研究包括50名向眼科门诊报告的VKC患者（ OPD）。年龄和性别相匹配的40名健康受试者作为对照。对病例和对照的血清AAT水平进行了评估和比较。此外，将出院时患者的血清AAT水平与治疗后三周后的血清AAT水平进行比较。结果：出院时VKC患者血清中的AAT水平（2.80±0.42 mg / ml）显着高于对照组（2.31±0.21 mg / ml），而治疗后VKC患者的血清水平（2.48±0.26 mg / ml）与对照组之间无显着差异。结论：AAT是一种有效的急性期蛋白，其浓度在VKC中显着升高，无论患者的年龄和性别如何。此外，治疗后血清AAT水平显着下降。因此它可以用作预后指标。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号