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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of Camphylobacter rectus on Serum Iron and Transferrin? In-Vivo Findings
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Effect of Camphylobacter rectus on Serum Iron and Transferrin? In-Vivo Findings

机译：直肌弯曲杆菌对血清铁和转铁蛋白的影响？体内发现

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Background and Aim: Periodontopathogens require iron constituents for their growth and metabolism in subgingival crevice. In this study, C.rectus was detected and quantified by using 16s rDNA based PCR in chronic periodontitis and compared with the levels of serum iron, total iron binding capacity and transferrin in chronic periodontitis and healthy sites. Materials and Methods: One hundred twenty subjects divided into chronic periodontitis and healthy controls. Deep subgingival plaque was collected and genomic DNA was extracted from each sample analysed for C.rectus using 16s rRNA based PCR analysis. Blood samples were collected from both groups for estimation of serum iron, serum total iron binding capacity and serum transferrin levels. The quantified bacterial count was compared with blood samples. C. rectus was detected in both groups. Results: There was significant increase in bacterial count in chronic periodontitis (p<0.05). Serum iron level was significantly raised in healthy group. TIBC and transferrin levels were elevated in periodontitis. Although these differences were non-significant. Regression analysis showed significant linear relationship between C.rectus counts and decreasing iron levels and consequently increasing serum transferrin and TIBC (p<0.05). Conclusion: The preliminary in vivo findings suggests C.rectus requires iron as a significant source of nutrition for its survival and growth form its hosts in deeper subgingival sites.
机译：背景与目的：牙周病原体需要铁成分才能在龈下缝隙中生长和代谢。在这项研究中，使用基于慢性牙周炎的16s rDNA PCR对直肠直肌进行了检测和定量，并与慢性牙周炎和健康部位的血清铁，总铁结合能力和转铁蛋白水平进行了比较。材料与方法：120位受试者分为慢性牙周炎和健康对照。收集深龈下斑块，并使用基于16s rRNA的PCR分析从每个样本中提取的基因组DNA进行直肠念珠菌提取。两组均采集血样以评估血清铁，血清总铁结合能力和血清转铁蛋白水平。将定量细菌计数与血样进行比较。两组均检测到直肠直肌。结果：慢性牙周炎的细菌计数显着增加（p <0.05）。健康组血清铁水平明显升高。牙周炎中TIBC和转铁蛋白水平升高。尽管这些差异不明显。回归分析显示直肠直肌计数与铁水平降低之间有显着的线性关系，因此血清转铁蛋白和TIBC升高（p <0.05）。结论：体内初步研究结果表明，直肠直肠念珠菌需要铁作为其在深龈下部位的宿主的生存和生长的重要营养来源。

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