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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of Citalopram in Combination with Omega-3 on Depression in Post-menopausal Women: A Triple Blind Randomized Controlled Trial
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Effect of Citalopram in Combination with Omega-3 on Depression in Post-menopausal Women: A Triple Blind Randomized Controlled Trial

机译：西酞普兰与Omega-3联合治疗对绝经后妇女抑郁的影响：三盲随机对照试验

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Introduction: Depressive disorder is a common and disabling disorder that causes high rates of morbidity and mortality. Citalopram is an antidepressant drug, of the Selective Serotonin Reuptake Inhibitor (SSRI) class that has been used for geriatric depression since a long time ago. Prescription of omega-3 in geriatric depression has been increased recently; because of more favorable profile of their side effects. Some of the studies reported that omega-3 is effective in prevention or treatment of depressive disorders than Citalopram. However, there are contradictory studies too.Aim: This study aimed to investigate the effect of a combination of omega-3 and citalopram in the treatment of women with post-menopausal depression.Materials and Methods: This triple-blind randomized controlled trial was conducted on 60 women with post-menopausal depression who were referred to the Hamadan Fatemieh Hospital. After the participants completed the DSM-IV questionnaire and depression was confirmed by a psychiatrist, participants were assigned randomly into two-intervention and control groups. The patients in the control group received 20mg citalopram along with a placebo while patients in the intervention group received 20mg citalopram and 1g of omega-3. At baseline and at the end of the first, second, and fourth weeks, all of the participants answered the Beck?s Depression Inventory (BDI). Descriptive statistics and t-test, repeated measures analysis of variance and Bonferroni post-hoc test was used to analyse the data.Results: The depression score was 6.1±2.41 in intervention and 25.22±10.04 in control group, four weeks after intervention. A decreasing trend was observed in the mean depression scores of the intervention group during the study. Using repeated measures analysis of variance, a significant difference was observed between the mean depression scores of the two groups at the four measurement time-points (p<0.001). The mean depression scores of the intervention group were significantly lower than the control group either two weeks (p< 0.001) or four weeks after the treatments (p< 0.001).Conclusion: Using omega-3, can reduce the severity of depression in post-menopausal women.
机译：简介：抑郁症是一种常见的致残性疾病，会导致较高的发病率和死亡率。西酞普兰是一种抗抑郁药，属于选择性5-羟色胺再摄取抑制剂（SSRI）类，自很久以来就一直用于老年抑郁症。最近在老年抑郁症中增加了omega-3的处方。因为它们的副作用更有利。一些研究报告说，与西酞普兰相比，omega-3在预防或治疗抑郁症方面有效。然而，也有一些矛盾的研究。目的：本研究旨在探讨omega-3和西酞普兰联合治疗绝经后抑郁症妇女的疗效。材料与方法：进行了这项三盲随机对照试验。 60名绝经后抑郁症的妇女被转诊到哈马丹·法特米耶医院。在参与者完成DSM-IV问卷并由精神科医生确认抑郁后，将参与者随机分为两个干预组和对照组。对照组的患者接受20mg西酞普兰和安慰剂，而干预组的患者接受20mg西酞普兰和1g omega-3。在基线以及第一，第二和第四周结束时，所有参与者都回答了贝克抑郁量表（BDI）。采用描述性统计和t检验，方差重复测量分析和Bonferroni事后检验对数据进行分析。结果：干预后4周，干预组抑郁评分为6.1±2.41，对照组为25.22±10.04。在研究期间，干预组的平均抑郁评分下降。使用重复测量方差分析，在四个测量时间点观察到两组的平均抑郁评分之间存在显着差异（p <0.001）。治疗后两周（p <0.001）或治疗后四周（p <0.001），干预组的平均抑郁评分均显着低于对照组。结论：使用omega-3可降低术后抑郁的严重程度-绝经期妇女。

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