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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient
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Fatal Nevirapine-Induced Toxic Epidermal Necrolysis in a HIV Infected Patient

机译：致命的奈韦拉平在HIV感染患者中引起的毒性表皮坏死溶解

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摘要

Stevens-Johnson Syndrome (SJS) and Toxic Epidermal Necrolysis (TEN) are the most Severe Cutaneous Adverse Reactions (SCARs) which mainly caused by exposure to drugs and having significant morbidity and mortality. TEN represents an immunologic reaction to a foreign antigen and is most often caused by drugs. Nevirapine (NVP), a non-nucleoside reverse transcriptase inhibitor (NNRTI) is an important component of Highly Active Antiretroviral Therapy (HAART). It is sometimes associated with life-threatening adverse reactions. Here, we report the fatal case of 72-year-old male who developed TEN secondary to intake of nevirapine. This fatal case report will increase awareness among treating physicians for careful monitoring of patients on NNRTI-based antiretroviral therapy and better counseling of the patient on NVP regimen for early identification and reporting of SCARs so that fatalities due to adverse drug reactions can be prevented with timely intervention.
机译：史蒂文斯－约翰逊综合症（SJS）和毒性表皮坏死症（TEN）是最严重的皮肤不良反应（SCAR），主要由接触药物引起，并具有较高的发病率和死亡率。 TEN代表对外源抗原的免疫反应，通常是由药物引起的。奈韦拉平（NVP）是一种非核苷类逆转录酶抑制剂（NNRTI），是高效抗逆转录病毒疗法（HAART）的重要组成部分。它有时与威胁生命的不良反应有关。在这里，我们报告了致命的一例，该病例是因摄入奈韦拉平而继发TEN的72岁男性。该致命病例报告将提高治疗医师的意识，以便他们对基于NNRTI的抗逆转录病毒疗法的患者进行仔细的监测，并为NVP方案的患者提供更好的咨询，以早期发现和报告SCAR，从而可以及时预防药物不良反应导致的死亡介入。

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