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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Cranial Neuroimaging in Infantile Tremor Syndrome: The Road Ahead
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Cranial Neuroimaging in Infantile Tremor Syndrome: The Road Ahead

机译：婴儿震颤综合征的颅神经影像学：未来之路

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Infantile Tremor Syndrome (ITS) is a self-limiting clinical state of unknown aetiology characterised by tremors, anaemia, pigmentary skin disease, regression of mental development and hypotonia of muscles in a plump looking child, mostly reported from Indian subcontinent.Aim: To analyse the role of cranial neuroimaging in identifying aetiology of ITS patients.Materials and Methods: This observational cross-sectional study done at Department of Paediatrics, RD Gardi Medical College, Ujjain, Madhya Pradesh, India, was conducted during the period of April 2013 to August 2014. Ten patients admitted with clinically diagnosed ITS were studied. Patient profiles, history, anthropometric measurements, general and systemic examination along with cranial neuroimaging were also studied.Results: Out of ten ITS patients, four were males and six females. Mothers of all children were vegetarian and Hindu by religion. Severe wasting was present in four patients whereas three had moderate wasting. On cranial neuroimaging non specific cerebral atrophy of different grades was observed in all cases except one and cerebellar atrophy in one case of ITS. Reduced thickness of corpus callosum was observed in six patients and nine children had prominence of Sylvian sulcus. Out of the four children with severe wasting three had evidence of cerebral atrophy; moreover, all the three patients having moderate wasting had evidence of cerebral atrophy.Conclusion: Different grades of cerebral atrophy, ventricular enhancement along with corpus callosum thinning have been the key findings in ITS patients. Findings support nutritional deficiencies as most probable aetiology.
机译：婴儿震颤综合征（ITS）是一种病因自限的临床状态，其病因不明，其特征是饱满的孩子体内震颤，贫血，色素性皮肤病，智力发育下降和肌肉张力减退，主要来自印度次大陆。目标：分析颅神经影像学在识别ITS患者病因中的作用。材料与方法：在观察期间，这项研究是在印度中央邦Ujjain RD Gardi医学院儿科系进行的。期间为2013年4月至2014年8月。研究了10例经临床诊断为ITS的患者。患者的概况，病史，人体测量学，全身和全身检查以及颅神经影像学也得到了研究。结果：在ITS患者中，十名中，男性为四名，女性为六名。所有孩子的母亲在宗教上都是素食主义者和印度教徒。四名患者出现严重的消瘦，而三名出现中度消瘦。在颅神经影像学检查中，除1例小脑萎缩和1例小脑萎缩外，所有病例均观察到不同程度的非特异性脑萎缩。在6例患者中观察到call体厚度减小，并且9名儿童患有Sylvian沟。在四名严重消瘦的儿童中，有三名有脑萎缩的证据。此外，三名中度消瘦的患者均有脑萎缩的证据。结论：不同程度的脑萎缩，心室增强以及call体变薄是ITS患者的主要发现。研究结果证明营养缺乏是最可能的病因。

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