Remimazolam (CNS 7056): anEmerging Sedative and GeneralAnaesthetic

Sumit Bansal; Shubha Singhal

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Remimazolam (CNS 7056): anEmerging Sedative and GeneralAnaesthetic

机译：Remimazolam（CNS 7056）：一种新兴的镇静药和全身麻醉药

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Remimazolam is a newer drug in the field of anaesthesia. It combines the properties of midazolam and remifentanil. As the name indicates, midazolam is the parent compound of remimazolam which incorporates the pharmacokinetic properties of remifentanil. Remimazolam is an ultra short acting anaesthetic agent/sedative which rapidly shows its effect after injection and also wears off expeditiously after cessation. Therefore, remimazolam?s dosage can be ideally controlled. Since it acts on benzodiazepine receptors, availability of specific antagonist (flumazenil) further adds to its safety in case of overdose.

机译：Remimazolam是麻醉领域的一种新药。它结合了咪达唑仑和瑞芬太尼的特性。顾名思义，咪达唑仑是remimazolam的母体化合物，具有remifentanil的药代动力学特性。 Remimazolam是一种超短效麻醉剂/镇静剂，在注射后迅速显示其作用，并且在戒断后迅速消失。因此，雷米唑仑的剂量可以理想地控制。由于它对苯并二氮杂pine受体起作用，因此在过量的情况下，特异性拮抗剂（氟马西尼）的可用性进一步增加了其安全性。

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《Journal of Clinical and Diagnostic Research》 |2018年第3期|共3页
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Sumit Bansal; Shubha Singhal;
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1. Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers Part II. Pharmacodynamics of Electroencephalogram Effects [J] . Anesthesiology . 2020,第4期

机译：在健康雄性志愿者的连续输注后，Remimazolam（CNS 7056）的药代动力学和药效学。脑电图效应的药效学
2. Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers Part II. Pharmacodynamics of Electroencephalogram Effects [J] . Anesthesiology . 2020,第4期

机译：在健康雄性志愿者的连续输注后，Remimazolam（CNS 7056）的药代动力学和药效学。脑电图效应的药效学
3. A phase III study evaluating the efficacy and safety of remimazolam (CNS 7056) compared with placebo and midazolam in patients undergoing colonoscopy [J] . Rex Douglas K., Bhandari Raj, Desta Taddese, Gastrointestinal Endoscopy . 2018,第3期

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4. Hamamatsu PMT R7056 study for the extinction monitoring system of the Mu2e experiment at Fermilab [C] . S. Boi, A. Dyshkant, D. Hedin, IEEE Nuclear Science Symposium and Medical Imaging Conference . 2015

机译：滨松PMT R7056在费米实验室的Mu2e实验灭绝监测系统中的研究
5. Novel interactions of LDL-receptor 1 (LRP1) with components of CNS myelin reveal LRP1 as a novel regulator of CNS regenerative failure after injury. [D] . Stiles, Travis L. 2013

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6. Population Pharmacokinetic/Pharmacodynamic Model-Guided Dosing Optimization of a Novel Sedative HR7056 in Chinese Healthy Subjects [O] . Ying Zhou, Pei Hu, Yuguang Huang, 2018

机译：新型镇静剂HR7056在中国健康受试者中的群体药代动力学/药效学模型指导剂量优化
7. Pharmacokinetics and Pharmacodynamics of Remimazolam (CNS 7056) after Continuous Infusion in Healthy Male Volunteers [O] . Jürgen Schüttler, Andreas Eisenried, Marco Lerch, 2020

机译：在健康男性志愿者的连续输注后雷马唑仑（CNS 7056）的药代动力学和药效学

Remimazolam (CNS 7056): anEmerging Sedative and GeneralAnaesthetic

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