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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Sympathetic Overactivity Predicts Microalbuminuria in Pregnancy
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Sympathetic Overactivity Predicts Microalbuminuria in Pregnancy

机译：交感神经过度活动可预测妊娠期微量白蛋白尿

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Microalbuminuria is a frequent feature in pregnancy, as the latter is a state of haemodynamic changes and sympathetic overactivity. Both sympathetic overactivity {as measured by Heart Rate Variability (HRV)} and microalbuminuria are individually linked with hypertension. So, presence of these conditions in pregnant women could be the reason for the increasing prevalence of Pregnancy Induced Hypertension (PIH)/Preeclampsia.Aim: To measure HRV and urinary microalbumin excretion simultaneously in pregnant women.Materials and Methods: In this hospital-based study, pregnant women in 2nd and 3rd trimester were recruited along with age-matched controls. Their sympathetic activity and urinary albumin-creatinine ratio were recorded. The patients were followed till delivery to note progression to preeclampsia/ pregnancy-induced hypertension. Statistical analysis was done with appropriate tests using Graphpad Prizm (version 7.04).Results: The level of urinary microalbumin was found to be high in the pregnant group. Albumin Creatinine Ratio (ACR) was raised in pregnancy (72.35±50.29 in third trimester, 84.48±52.61 in second trimester and 17.59±6.19 in non-pregnant control group; p<0.001). The HRV study shows that sympathetic dominance is more during pregnancy as compared to non-pregnant (2.09±0.91 in pregnant and 1.04±0.65 in non-pregnant group).Conclusion: It was concluded that there is a neurogenic role for the causation of microalbuminuria in pregnancy. As this condition predicts the development of pre-eclampsia/eclampsia in later pregnancy, all the methods targeting generalised stress reduction could be advised to all pregnant women during their first visit.
机译：微量白蛋白尿是妊娠的常见特征，因为后者是血液动力学变化和交感神经过度活动的状态。交感神经过度活动（如通过心率变异性（HRV）测量）和微量白蛋白尿均与高血压有关。因此，孕妇中这些疾病的存在可能是妊娠高血压（PIH）/先兆子痫患病率增加的原因。目的：同时测量孕妇中的HRV和尿微量白蛋白排泄。材料和方法：在这项基于医院的研究中，招募了妊娠中期和晚期的孕妇以及年龄匹配的对照组。记录他们的交感神经活动和尿白蛋白-肌酐比值。随访患者直至分娩，注意进展为先兆子痫/妊娠诱发的高血压。使用Graphpad Prizm（7.04版）通过适当的测试进行统计分析。结果：发现孕妇组中的尿微量白蛋白水平很高。怀孕时白蛋白肌酐比率（ACR）升高（妊娠中期72.35±50.29，妊娠中期84.48±52.61，非妊娠对照组17.59±6.19; p <0.001）。 HRV研究表明，与未怀孕相比，怀孕期间的交感优势更为明显（怀孕组为2.09±0.91，非怀孕组为1.04±0.65）。妊娠微量白蛋白尿的病因。由于这种情况预示着妊娠后期先兆子痫/子痫的发展，所有针对一般性压力减轻的方法都可建议所有孕妇在首次就诊时使用。

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