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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Histomorphological Lung Changes and Cause of Death Correlation: An Autopsy Based Study in a Tertiary Care Centre
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Histomorphological Lung Changes and Cause of Death Correlation: An Autopsy Based Study in a Tertiary Care Centre

机译：组织形态学肺变化和死亡相关原因：在三级护理中心的尸检研究。

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Organ-specific pathological changes that are seen during autopsy give a clearer picture of the cause of death and help to correlate with the clinical scenario.Aim: To study the histomorphological lung changes seen at autopsy and to correlate them with the clinical cause of death.Materials and Methods: Lung specimens were collected from 120 autopsies conducted at a tertiary care hospital in coordination with the Department of Forensic Medicine during a two-year period. Grossly, both lungs were carefully examined for any morphological changes. Histological studies were performed on the representative bits taken. The sections were examined for congestion, oedema, haemorrhage, hyaline membranes, inflammation, alveolar collapse/thinning, alveolar wall disturbances, capillary dilatation and micro-organisms.Results: Majority of patients belonged to the third decade of life. The most common cause of death was Road Traffic Accidents (RTAs). Majority RTA victims were males and all burns victims were females. The commonly seen morphological features were pulmonary congestion, pulmonary oedema and alveolar haemorrhage. Diffuse Alveolar Damage (DAD) was only seen in 13.5% of cases.Conclusion: The histological findings seen in the RTA cases were associated with circulatory failure manifesting in the lungs as alveolar haemorrhage, congestion and oedema, microvascular damage and eventually multi-organ injury. DAD was more commonly observed in cases of poison and burns than in RTAs. The most frequent manner of deaths was accidents (RTA), followed by suicides (poisoning and burns) and sudden death. Autopsy including histology plays an important role in the evaluation of the cause of death.
机译：尸检过程中观察到的器官特异性病理变化可以更清楚地了解死亡原因，并有助于与临床情况相关。目的：研究尸检时发现的组织形态学肺部变化并将其与临床原因相关联材料和方法：在两年的时间里，与法医学部协作，从三级医院进行的120例尸检中收集肺标本。大体上，仔细检查了两个肺的任何形态变化。对所取的代表性钻头进行组织学研究。检查了这些切片的充血，水肿，出血，透明膜，炎症，肺泡塌陷/变薄，肺泡壁紊乱，毛细血管扩张和微生物。结果：大多数患者属于生命的第三十年。最常见的死亡原因是道路交通事故（RTA）。大多数RTA受害者是男性，所有烧伤受害者都是女性。常见的形态特征是肺充血，肺水肿和肺泡出血。仅在13.5％的病例中发现弥漫性肺泡损害（DAD）。结论：RTA病例中观察到的组织学发现与肺循环衰竭相关，表现为肺泡出血，充血和水肿，微血管损害，最终多发-器官损伤。与RTAs相比，DAD在中毒和烧伤中更常见。最常见的死亡方式是事故（RTA），其次是自杀（中毒和烧伤）和猝死。包括组织学在内的尸检在评估死因方面起着重要作用。

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