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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Adult Neuroblastoma-Case Report and Literature Review
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Adult Neuroblastoma-Case Report and Literature Review

机译：成人神经母细胞瘤病例报告和文献复习

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Neuroblastoma is the most common solid malignant neoplasm in the paediatric age group; accounting for 7% of all childhood malignancies, but neuroblastoma in adult, is a rare occurrence finding mention in aeons in medical literature with an overall incidence of 1 in 10 million adults/year. We report the case of a 24-year-old male patient presenting with the complaints of progressive abdominal distention of 2 months duration. Multiple Detector Computed Tomography (MD-CT) of abdomen revealed a huge enhancing mass in the retroperitoneum abutting the left kidney, and a subsequent CT-guided biopsy and immunohistochemistry confirmed the diagnosis of ganglioneuroblastoma. The patient was administered 3-cycles of neo-adjuvant chemotherapy with ifosphamide, carboplatin and etoposide (ICE-chemotherapy) and subsequently 3 more cycles of chemotherapy post surgery, followed by radiation. The rarity of this neoplasm in adults accounts for the lack of standardized staging and treatment protocols and the dismal prognosis even with aggressive multimodal treatment. We report this case because of its extreme rarity, and its tendency for capricious behavior.
机译：神经母细胞瘤是儿童年龄组中最常见的实体恶性肿瘤。占所有儿童恶性肿瘤的7％，但成人中的神经母细胞瘤很少见，在医学文献中屡屡提及，其总发病率为1000万成年人/年。我们报告了一名24岁男性患者的病例，该患者患有持续2个月的进行性腹胀。腹部的多重检测计算机断层扫描（MD-CT）显示，紧接左肾的腹膜后腹膜巨大肿块，随后的CT引导活检和免疫组织化学证实了神经节神经母细胞瘤的诊断。对该患者进行了3个周期的新辅助化疗，包括异环磷酰胺，卡铂和依托泊苷（ICE化疗），随后在手术后进行了另外3个周期的化疗，然后进行放射治疗。这种肿瘤在成人中的稀有性导致缺乏标准的分期和治疗方案，即使进行积极的多式联运治疗也预后不良。我们报告这种情况是因为它极少见，而且反复无常。

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