...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Serum FRAP Levels and Pre-eclampsia among Pregnant Women in a Rural Community of Northern India
【24h】

Serum FRAP Levels and Pre-eclampsia among Pregnant Women in a Rural Community of Northern India

机译：印度北部农村社区孕妇的血清FRAP水平和先兆子痫

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: There is a balance between the oxidative and the anti-oxidative forces in human body. Some studies document decreased level of anti-oxidant in pre-eclampsia while other studies showed normal level of anti-oxidant in pre-eclampsia and the evidence is equivocal.Aim: The aim of the present study was to assess enzymatic anti-oxidant activities in pre-eclamptic women and compare it with normotensive pregnant women with period of gestation between 28 to 36 weeks.Materials and Methods: A community-based cross-sectional survey was conducted (from November 2012-December 2013) at the Ballabgarh Health and Demographic Surveillance System (HDSS) site which was managed by Centre for Community Medicine, All India Institute of Medical Sciences, New Delhi, India. All registered pregnant women with period of gestation between 28 weeks ? 36 weeks were eligible for inclusion in the study. All eligible pregnant women were contacted through home visit. A total of 217 pregnant women were enrolled out of which 209 blood samples were collected from pregnant women. About three ml of blood from antecubital vein was drawn without use of tourniquet, under aseptic conditions. It was later analysed for the serum anti-oxidative measures {Malanoaldehyde, Vitamin C, Ferric Reducing Ability of Plasma (FRAP) levels}. Data were entered on Epi-Info version 3.5.4. Data management and analysis was carried out in Stata 11. The means were compared using t-test and p-value stated. Categorical data was analysed using chi-square test. Logistic regression was used and adjusted p-value was stated.Results: A total of 217 pregnant women were eligible for the study and all were enrolled. Out of the 217 blood samples collected, eight samples accidently got destroyed. A total of 28 out of remaining 209 pregnant women (13.4%) had pre-eclampsia. Mean age (SD) was 22.4 (2.3) years, mean height (SD) was 156.6 (6.9) cm, mean weight (SD) was 65.1 (9.7) kg in pre-eclampsia group. In pre-eclampsia group mean serum levels of malanoaldehyde, vitamin C and FRAP was 4.2 (0.26) ng/dl, 0.83 (0.11) mg/dl, 678.0 (35.6) μmol/L. It was 4.5 (0.09) ng/dl,0.88 (0.03) mg/dl, 599.3 (13.3) μmol/L in normotensive pregnant women group respectively. The difference was statistically significant for FRAP levels only.Conclusion: Serum anti-oxidant levels are not raised among women with pre-eclampsia.
机译：简介：人体的氧化力和抗氧化力之间是平衡的。一些研究表明先兆子痫中抗氧化剂的水平降低，而另一些研究表明先兆子痫中抗氧化剂的水平正常，证据是模棱两可的。先兆子痫妇女，并将其与妊娠期在28至36周之间的血压正常的孕妇进行比较。材料与方法：在Ballabgarh健康与人口监测部进行了一项基于社区的横断面调查（从2012年11月至2013年12月）。系统（HDSS）站点由印度新德里全印度医学科学研究所社区医学中心管理。所有已登记孕妇的妊娠期在28周之间？ 36周有资格纳入研究。通过家访与所有符合条件的孕妇进行了联系。总共招募了217名孕妇，其中从孕妇那里采集了209个血液样本。在无菌条件下，不使用止血带从肘前静脉抽取约3毫升血液。随后对其进行了血清抗氧化措施{丙二醛，维生素C，血浆铁还原能力（FRAP）水平}的分析。在Epi-Info版本3.5.4上输入数据。在Stata 11中进行数据管理和分析。使用t检验和p值比较平均值。使用卡方检验分析分类数据。结果：共有217名孕妇符合研究条件，并全部纳入研究。在收集的217个血液样本中，有八个样本被意外破坏。其余209名孕妇中共有28名（13.4％）患有先兆子痫。先兆子痫组的平均年龄（SD）为22.4（2.3）岁，平均身高（SD）为156.6（6.9）cm，平均体重（SD）为65.1（9.7）kg。子痫前期组中丙二醛，维生素C和FRAP的平均血清水平为4.2（0.26）ng / dl，0.83（0.11）mg / dl，678.0（35.6）μmol/ L。血压正常的孕妇组分别为4.5（0.09）ng / dl，0.88（0.03）mg / dl，599.3（13.3）μmol/ L。结论：子痫前期妇女的血清抗氧化水平并未升高。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号