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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Effect of Myristica fragrans Extract on Food Intake and Body Weight in Experimental Models
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Effect of Myristica fragrans Extract on Food Intake and Body Weight in Experimental Models

机译：实验模型中豆蔻提取物对食物摄入和体重的影响

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Myristica fragrans (Mace) is one of the commonly used Indian spices. It was used in traditional medicine to treat digestive problems, rheumatism, hyperlipidaemia, diarrhoea and insomnia. More food intake than required on a daily basis, can lead to overweight Body Mass Index (BMI 25-30) or Obesity (BMI >30). Herbal supplements and diet based therapies for weight loss are among the most common in Complementary and Alternative Medicine (CAM) modalities. Myristica fragrans (M. fragrans) contains Tetrahydrofuran (THF), Lignans. Saponins, flavonoids, glycosides, tannins and terpenoids. These chemical compounds are believed to have anti-obesity properties. Hence, Mace extract was selected to observe its effect on food intake and body weight.Aim: To evaluate the effect of M. fragrans extract on food intake and body weight in normal and obese wistar albino rats.Materials and Methods: Healthy albino rats (male/female) weighing between 150-180 gm were selected and randomly divided into five groups with six rats each. Body weight of all rats was recorded on day one. From day one to day 35 (five weeks), Body weight (BW) and Food intake (FI) capacity of an individual rat per day and for 35 days was measured in all the groups before treatment with M. fragrans extract. Group-I (Control) was treated with standard pellet diet and normal saline, Group-II (Test 1) with M. fragrans extract 200 mg/kg and Group-III (Test 2) with Myristica fragrans Extract (MFE) 400 mg/kg for 35 days (day 36 to day 70). Group IV (Test 3) and V (Test 4) were given Cafeteria Diet (CD) to induce obesity for first five weeks and last five weeks treated with M. fragrans Extract in the doses of 200 mg/kg and 400 mg/kg respectively. On day 70, FI capacity and BW of each rat was measured statistically using SPSS Statistics 20.0 (IBM software) for the analysis. Animals were observed for FI capacity and BW for 70 days (first 35 days and last 35 days).Results: Repeated measures one-way analysis of variance (ANOVA) indicated that, after 35 days of treatment (between 36-70 days), there was a significant reduction of FI capacity and BW in Group III and V, and slightly reduced in Group-II and IV in a dose dependent manner (p<0.01) but there was no difference in Group-I animals.Conclusion: These results suggest that M. fragrans extract may have clinical value in the treatment of obesity due to its inhibitory effect on FI capacity (by inhibiting hunger sensory mechanism) and BW by inhibiting pancreatic lipase enzyme.
机译：肉豆蔻（Macrist）是常用的印度香料之一。它在传统医学中用于治疗消化系统疾病，风湿病，高脂血症，腹泻和失眠。食物摄入量超过每日所需量，会导致体重指数（BMI 25-30）或肥胖（BMI> 30）超重。在补充和替代医学（CAM）模式中，最常用的草药补充剂和基于饮食的减肥方法。肉豆蔻（M. fragrans）含有四氢呋喃（THF），木质素。皂苷，类黄酮，糖苷，单宁和萜类化合物。这些化合物被认为具有抗肥胖特性。因此，选择梅斯提取物以观察其对食物摄入和体重的影响。目的：评估苦参提取物对正常和肥胖的维斯塔白化病大鼠食物摄入和体重的影响。材料和方法：选择体重在150-180 gm之间的健康白化病大鼠（雄性/雌性），将其随机分为五组，每组六只。在第一天记录所有大鼠的体重。从第一天到第三十五天（五周），在使用fragerrans提取物治疗之前，对所有组的每只大鼠每天和连续35天的体重（BW）和食物摄入（FI）能力进行测量。第I组（对照组）用标准颗粒饲料和生理盐水处理，第II组（试验1）用200 mg / kg的苦参提取物和第III组（试验2）用400 mg / kg肉豆蔻提取物处理千克，持续35天（第36天到第70天）。分别以200 mg / kg和400 mg / kg的剂量对fragrans提取物进行治疗的前五周和后五周，对IV组（测试3）和V组（测试4）分别进行自助饮食（CD）诱导肥胖。在第70天，使用SPSS Statistics 20.0（IBM软件）对每只大鼠的FI容量和BW进行统计学测量以进行分析。观察动物的FI能力和体重，持续70天（前35天和后35天）。结果：重复测量单向方差分析（ANOVA）表明，治疗35天后（36-70之间）天），III和V组的FI能力和BW显着降低，II和IV组以剂量依赖的方式略有降低（p <0.01），但I组动物没有差异。 b>结论：这些结果表明，苦参提取物可能通过抑制胰腺脂肪酶对FI容量（通过抑制饥饿感官机制）和BW的抑制作用而在肥胖症治疗中具有临床价值。

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