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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Seroprevalence of Rubella Antibodies in Infertile and Pregnant Sudanese Women
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Seroprevalence of Rubella Antibodies in Infertile and Pregnant Sudanese Women

机译：不育和怀孕的苏丹妇女的风疹抗体的血清阳性率。

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Primary rubella leads to serious consequences in pregnant women such as abortion, stillbirth and severe birth defect. Vaccination is the best strategy to give acquired immunity and to prevent the disease. However, screening women at reproductive age for rubella is not routinely used in many resource-limited countries like Sudan and data on prevalence of the disease lacks accurate information.Aim: We aimed to determine anti-Rubella IgM and IgG antibody profile of infertile women in Sudan to assess possible association of rubella with women infertility.Materials and Methods: This was a cross-sectional study conducted during April-July 2016 where a total number of 184 serum specimens were collected. Specimens included 92 sera of infertile women collected in antenatal care hospital for fertility in Khartoum and 92 sera collected from healthy pregnant women, as controls. Sera were screened for anti-Rubella IgM and IgG antibodies using ELISA kits (Fortress Diagnostics, UK).Results: Socio-demographic and clinical information were obtained from infertile women using a structured questionnaire and were analysed using Pearson?s Chi-square test by SPSS program version 16. Seropositivities of anti-Rubella antibodies among infertile women were found to be 75% (69/92) for IgM and 94.5% (87/92) for IgG. These values increased with age; however, there were no statistical differences among the different age groups. Interestingly, all infertile women at the age above 46 years demonstrated presence of IgM and IgG, accounting 100% seropositivity. A statistically significant difference was observed in the seropositivity of anti-Rubella IgM antibodies among infertile women of different duration of marriage (p-value 0.025). Among pregnant women (control group), 14.1% (13/92) and 92.40% (85/92) were positive for anti-Rubella IgM and IgG antibodies, respectively.Conclusion: The high anti-Rubella IgG antibody titres among the two cohorts in the absence of routine vaccination in the country suggest high endemicity and sustained transmission. Additionally, the higher IgM antibody titers among the infertile women suggest potential role of rubella to impair women fertility. Further studies are needed to determine high risk population and the need for an immunization policy for rubella in Sudan.
机译：原发性风疹会给孕妇带来严重后果，例如流产，死产和严重的先天缺陷。接种疫苗是获得后天免疫力和预防疾病的最佳策略。但是，在苏丹这样的许多资源有限的国家中，常规不使用育龄妇女筛查风疹的方法，而且该疾病的流行率数据缺乏准确的信息。目标：我们旨在确定抗风疹IgM和IgG抗体的概况苏丹不育妇女评估风疹与妇女不育的可能关系。材料与方法：这是一项横断面研究，于2016年4月至7月进行，收集了184个血清标本。标本包括在喀土穆的产前保健医院收集的92例不育妇女的血清和作为对照的92例健康孕妇的血清。使用ELISA试剂盒（英国Fortress Diagnostics）对血清进行抗Rugella IgM和IgG抗体的筛查。结果：使用结构化问卷从不育妇女中获得了社会人口统计学和临床​​信息，并使用Pearson？s Chi-由SPSS程序版本16进行的平方检验。发现不育女性中抗Rubella抗体的血清学阳性率为IgM的75％（69/92）和IgG的94.5％（87/92）。这些值随着年龄的增长而增加。但是，不同年龄组之间没有统计学差异。有趣的是，所有46岁以上的不育妇女均表现出IgM和IgG的存在，占血清阳性的100％。在不同结婚年限的不育妇女中，抗Rubella IgM抗体的血清阳性率存在统计学差异（p值0.025）。在孕妇（对照组）中，抗Rugella IgM和IgG抗体阳性的比例分别为14.1％（13/92）和92.40％（85/92）。结论：抗Rubella IgG抗体滴度高该国没有常规疫苗接种的两个队列表明，该地区的高流行和持续传播。此外，不育妇女中较高的IgM抗体滴度表明风疹可能损害妇女的生育能力。需要进行进一步的研究以确定苏丹的高风险人群以及对风疹的免疫政策。

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