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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Ultrasound Evaluation of Foetal NasalBone and Maxillary Bone Length inthe Second and Third Trimester
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Ultrasound Evaluation of Foetal NasalBone and Maxillary Bone Length inthe Second and Third Trimester

机译：妊娠中期妊娠中期胎儿鼻骨和上颌骨长度的超声检查

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Genetic diseases are the major causes of perinatal death and childhood disabilities. Fetus with a genetic disease have either major structural malformation or minor abnormalities (known as markers) that are detected during sonographic examination. Antenatal ultrasonography now permits the measurement of numerous parts of the fetal body, and nomograms have been developed that help to distinguish normal from abnormal fetal biometry.Aim: 1) To define a nomogram for Nasal and Maxillary bone length in the local population of Salem. 2) To assess the correlation between nasal bone and maxillary bone length with bi-parietal diameter, Head Circumference (HC), Abdominal Circumference (AC) and Femur Length (FL).Materials and Methods: The present study was a prospective, cross-sectional study conducted in Department of Radiodiagnosis, Vinayaka Missions Medical College, Salem Tamil Nadu, India. Study was conducted for period of one year from September 2012-September 2013. A total of 250 patients with routine antenatal check-up scan were included in the study. Measurement of Bi-Parietal Diameter (BPD), HC, AC, FL, NBL, MBL with 5th, 50th and 95th percentiles of each parameter was calculated. Pearson's correlation coefficients were calculated to examine the strength of the linear relationship between the nasal and maxillary bone with gestational age, BPD, HC, AC, and FL. For each parameter, regression analysis was used as a dependent variable to calculate the equation of the linear fitted function with each of the independent variables.Results: The maternal age ranged from 17 years to 37 years. The gestational age by Last Menstrual Period (LMP) ranged from 12 weeks to 40 weeks. The mean nasal bone length increased linearly with gestational age from 2.9 mm at 12 weeks to 13.1 mm at 40 weeks. The mean maxillary bone length increased linearly with gestational age from 8.7 mm at 12 weeks to 15.6 mm at 40 weeks. Significant statistical correlation was found between nasal and maxillary bone length and BPD, HC, AC and FL.Conclusion: Normative data for ultrasonographic measurements of the fetal nasal and maxillary bone lengths throughout pregnancy are provided for the local population of Salem Tamil Nadu, India. These data potentially allow the prenatal diagnosis of abnormal nasal and maxillary bone length which is a marker for chromosomal defects.
机译：遗传疾病是围产期死亡和儿童期残疾的主要原因。患有遗传疾病的胎儿在超声检查过程中被发现具有严重的结构畸形或较小的异常（称为标记）。产前超声检查现在可以测量胎儿身体的许多部位，并且已经开发出有助于区分正常胎儿生物统计学和异常胎儿生物统计学的列线图。目标：1）在当地人群中定义鼻和上颌骨长度的列线图塞勒姆。 2）评估鼻骨和上颌骨长度与双顶径，头围（HC），腹围（AC）和股骨长度（FL）的相关性。材料与方法：本研究是一项前瞻性研究，在印度塞勒姆泰米尔纳德邦Vinayaka Missions医学院放射诊断学系进行的横断面研究。从2012年9月至2013年9月进行了为期一年的研究。该研究共纳入250例接受常规产前检查的患者。计算了每个参数的第5，第50和第95个百分位数的双顶径（BPD），HC，AC，FL，NBL，MBL的测量值。计算皮尔逊相关系数以检验鼻和上颌骨与胎龄，BPD，HC，AC和FL之间线性关系的强度。对于每个参数，将回归分析用作因变量，以计算每个独立变量的线性拟合函数方程。结果：产妇年龄在17岁至37岁之间。上次月经（LMP）的胎龄为12周至40周。平均胎骨长度随胎龄线性增加，从第12周的2.9 mm增加到第40周的13.1 mm。平均上颌骨长度随胎龄线性增加，从第12周的8.7 mm增加到第40周的15.6 mm。在鼻和上颌骨长度与BPD，HC，AC和FL之间发现了显着的统计相关性。结论：为塞勒姆·泰米尔·纳德邦的当地人口提供了整个怀孕期间胎儿鼻和上颌骨长度的超声测量正常数据。 ，印度。这些数据潜在地允许产前诊断鼻和上颌骨长度异常，这是染色体缺陷的标志。

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