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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Utility of Ovarian Tumour Marker Cancer Antigen-125 and Endocrine Hormonal Status in Polycystic Ovary Syndrome
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Utility of Ovarian Tumour Marker Cancer Antigen-125 and Endocrine Hormonal Status in Polycystic Ovary Syndrome

机译：卵巢肿瘤标志物癌抗原125和多囊卵巢综合征内分泌激素状态的实用性。

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Polycystic Ovary Syndrome (PCOS) is the most common endocrinopathy in women of reproductive age. Women with PCOS are at increased risk of reproductive abnormalities with a prevalence of up to 10%.Aim: To assess the concentrations of ovarian tumour marker Cancer Antigen-125 (CA125), Luteinizing Hormone (LH), Follicle Stimulating Hormone (FSH) And Prolactin (PRL) among women with PCOS in order to get insight of how these biochemical parameters play a crucial role in the pathogenesis of PCOS and to evaluate their diagnostic utility.Materials and Methods: A total of 60 subjects were enrolled for the prospective comparative case-control study. Out of these 60 subjects, a healthy control group of 30 subjects with non-hirsute, non-obese women with regular menstrual cycles were included as control. PCOS group of 30 women were selected as a study group who were already diagnosed by clinician. Their height (meters) and weight (kg) were measured and recorded. This measurement was used for calculating Body Mass Index (BMI) in kg/m2. Serum CA-125, LH, FSH and PRL were estimated by the chemiluminescent method on Immulite 1000. Data were presented as number, percentage, mean and standard deviation. Statistical analysis was done by normal distribution z-test.Results: The statistical significant alterations were observed in the levels of CA125, LH and PRL between PCOS group and control group. FSH level was insignificantly different in PCOS as compared with that of controls.Conclusion: An ovarian tumour marker CA125 and endocrine hormones such as LH, FSH and PRL are of paramount importance for the correct diagnosis with degree of severity in patients with PCOS. The present study confirms the elevated levels of LH as a regular feature of PCOS. Also, the possible correlation of CA125 and PRL in women having PCOS suggests that the combination of the ovarian tumour marker and this hormonal status can be used in biochemical screening of ovarian cancer. However, further prospective and controlled studies are needed to investigate their utility in prediction of ovarian cancer in women having PCOS.
机译：多囊卵巢综合征（PCOS）是育龄妇女最常见的内分泌病。具有PCOS的女性生殖异常风险增加，患病率高达10％。目标：评估卵巢肿瘤标志物Cancer Antigen-125（CA125），促黄体激素（LH），促卵泡激素（为了了解这些生化参数如何在PCOS的发病机理中发挥重要作用并评估其诊断效用，对PCOS妇女进行了FSH和催乳激素（PRL）研究。材料和方法：共有60名受试者参加了前瞻性比较病例对照研究。在这60名受试者中，有30名健康受试者的健康对照组，这些受试者有月经周期规律的非-割，非肥胖女性。选择由30名妇女组成的PCOS组作为研究组，他们已经被临床医生诊断。测量并记录其身高（米）和体重（kg）。该测量用于计算体重指数（BMI），单位为kg / m2。通过化学发光法在Immulite 1000上评估血清CA-125，LH，FSH和PRL。数据以数量，百分比，均值和标准差表示。通过正态分布z检验进行统计分析。结果：PCOS组和对照组之间的CA125，LH和PRL水平发生了统计学上的显着变化。结论：卵巢肿瘤标志物CA125和内分泌激素（如LH，FSH和PRL）对于正确诊断PCOS的严重程度至关重要。 。本研究证实了升高的LH水平是PCOS的常规特征。同样，在患有PCOS的女性中CA125和PRL的可能相关性表明，卵巢肿瘤标志物与这种激素状态的组合可用于卵巢癌的生化筛查。但是，需要进一步的前瞻性和对照研究来研究其在预测患有PCOS的女性卵巢癌中的作用。

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