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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats
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Red Lentil Extract: Neuroprotective Effects on Perphenazine Induced Catatonia in Rats

机译：红扁豆提取物：对奋乃静诱导的大鼠卡塔托尼亚的神经保护作用

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Introduction: Parkinsonism is a neurodegenerative disease that is defined by certain symptoms such as muscle rigidity, impaired movement, catatonia, tremor and disorientation of body.Aim: The aim was to investigate the effect of red lentil extract on perphenazine-induced Catatonia in model of rat.Materials and Methods: This experimental study was done on 48 male albino rats (weight 180?200g) of the Sprague-Dawley strain. Animals were randomly divided into six groups and were pre-treated with a single dose of red lentil extract (200, 400, 800 and 1000 mg/kg), most effective dose of bromocriptine (30mg/kg) and normal saline (5ml/kg) via intraperitoneal (IP) route. perphenazine (5 mg/kg) was after 30 minutes, administered (IP) to induce catatonia. The scoring method of Morpurgo was used to determine the muscular rigidity of animals.Results: The results showed that the 200mg/kg red lentil extract treated group had no significant reduction in catatonic responses after perphenazine administration in comparison with control group while the groups that received 800 and 1000mg/kg of red lentil extract showed significant difference (p<0.05) at all the time points.Conclusion: The results revealed that hydroalcoholic extract of red lentil has protective effect on Catatonia induced by perphenazine in rats. So this extract may be probably beneficial for catatonia in Parkinsonism.
机译：简介：帕金森病是一种神经退行性疾病，其定义为某些症状，例如肌肉僵硬，运动受损，卡塔顿尼亚，震颤和身体迷失方向。目的：研究红扁豆提取物对奋乃静诱导的卡塔顿尼亚模型的影响材料与方法：本实验是对48只Sprague-Dawley品系雄性白化病大鼠（体重180-200g）进行的。将动物随机分为六组，并用单剂量的红色小扁豆提取物（200、400、800和1000 mg / kg），最有效剂量的溴隐亭（30mg / kg）和生理盐水（5ml / kg）进行预处理）通过腹膜内（IP）路线。 30分钟后给予奋乃静（5 mg / kg），进行腹膜内注射（IP）诱导卡塔尼亚。结果：结果表明，与对照组相比，给予奋乃静的200mg / kg红扁豆提取物治疗组与对照组相比，奋乃静给药后的猫紧张反应无明显降低。在所有时间点，红扁豆提取物分别为800和1000mg / kg，差异有统计学意义（p <0.05）。结论：红扁豆水醇提取物对奋乃静致大鼠卡塔尼亚具有一定的保护作用。因此，这种提取物可能对帕金森病中的卡塔顿病有益。

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