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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis ofLichen Planus and Lichenoid Mucositis ZC84-ZC86
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Memory T Cells (CD45RO) Role and Evaluation in Pathogenesis ofLichen Planus and Lichenoid Mucositis ZC84-ZC86

机译：记忆T细胞（CD45RO）在扁平苔藓和类苔质粘膜炎ZC84-ZC86发病中的​​作用及评价

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Introduction: Memory T cells have the ability to survive in a quiescent state for longer periods and are responsible for the rapid responses on subsequent exposure to antigen. Analyzing memory T cells in Oral Lichen planus (OLP) and Lichenoid Mucositis (LM) suggest that these cells may play a role in the immunopathogenic mechanisms.Aim: To identify and evaluate Memory T cells in Lichen Planus (LP), Lichenoid Mucositis (LM) and Normal Mucosa (NM) using CD45RO monoclonal antibody immunohistochemically.Materials and Methods: A total of 30 cases (15 cases of OLP and 15 cases of LM) clinically and histopathologically diagnosed, and 10 cases of NM were stained for CD45RO monoclonal antibody, immunohistochemically using Biotin Streptavidin method. Staining intensity of CD45RO expression was statistically analysed using Chi-square Test.Results: The present study demonstrated a higher expression of CD45RO in connective tissue layer of OLP (53.3% intense staining) when compared to LM (20% intense staining) and no intense staining in NM. The difference in staining intensity pattern between the study groups was statistically significant (p=0.014).Conclusion: This study demonstrates a statistically significant rise in memory T cells in LP than in LM, indicating the possible different immunopathogenic mechanisms.
机译：简介：记忆T细胞具有在静止状态下存活更长时间的能力，并负责随后暴露于抗原时的快速反应。对口腔扁平苔藓（OLP）和苔藓样黏膜炎（LM）的记忆T细胞进行分析表明，这些细胞可能在免疫病理机制中起作用。材料和方法：临床和组织病理学共诊断30例（15例OLP和15例LM），并用CD45RO单克隆抗体对正常黏膜（NM）进行了CD45RO单克隆抗体染色，使用生物素链霉亲和素方法进行免疫组织化学分析。使用卡方检验对CD45RO表达的染色强度进行统计学分析。结果：本研究表明，与LM（20％强烈染色）相比，OLP结缔组织层中CD45RO的表达更高（53.3％强烈染色），而LM则没有。在NM染色。研究组之间的染色强度模式差异具有统计学意义（p = 0.014）。结论：这项研究表明，与LM相比，LP的记忆T细胞有统计学上的显着升高，表明可能存在不同的免疫致病机制。

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