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首页> 外文期刊>Journal of Clinical and Diagnostic Research >A Correlation Study on Apolipoprotein Ratio and Malondialdehyde in Patients with Type 2 Diabetes Mellitus
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A Correlation Study on Apolipoprotein Ratio and Malondialdehyde in Patients with Type 2 Diabetes Mellitus

机译：2型糖尿病患者载脂蛋白比率与丙二醛的相关性研究

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Type 2 Diabetes Mellitus (DM) is associated with hyperglycemia, dyslipidemia and oxidative stress. Oxidative damage, indicated by elevated levels of Malondialdehyde (MDA), plays a vital role in development of Coronary Artery Disease (CAD) in diabetics. Although reduction of Low Density Lipoprotein (LDL) is identified as the primary target for therapy in dyslipidemic patients by National Cholesterol Education Programme (NCEP), the levels of LDL may not be elevated in diabetic patients. Moreover, many studies have shown that apolipoprotein B100 and A1 (Apo B100 and Apo A1),which are the corresponding protein components of LDL and High Density Lipoproteins (HDL) respectively, are more sensitive markers for screening of CAD.Aim: To determine the concentration of Apo A1 and Apo B100 along with serum MDA in patients with type 2 DM and study the correlation between them.Materials and Methods: A case-control study was done on 75, type 2 diabetic patients and 75 healthy controls. Fasting plasma glucose, glycated hemoglobin, fasting lipid profile along with Apo A1, Apo B100 and MDA as a marker for lipid peroxidation were determined, compared and analyzed using Statistical Package for Social Sciences (SPSS) version 23.0.Results: Diabetic patients had a significantly higher levels of serum triglyceride, Apo B100 and MDA along with significantly lower levels of HDL and Apo A1. The Apo B100/Apo A1 ratio was also higher in diabetic cases which showed a strong positive correlation with HbA1c (r=0.515) and MDA (r=0.819). The levels of total cholesterol and LDL were comparable in both the groups.Conclusion: Diabetes mellitus is associated with dyslipidemia and oxidative stress. Poor glycemic control is associated with an increased oxidative damage which contributes to development of microvascular complication. Hence, Apo A1, Apo B100 and serum MDA may be included as additional parameters in the management of DM as they could help in early diagnosis and prevention of CAD.
机译：2型糖尿病（DM）与高血糖，血脂异常和氧化应激相关。丙二醛（MDA）水平升高表明氧化损伤在糖尿病患者冠状动脉疾病（CAD）的发展中起着至关重要的作用。尽管低密度脂蛋白（LDL）的降低已被国家胆固醇教育计划（NCEP）确定为血脂异常患者治疗的主要目标，但糖尿病患者的LDL水平可能不会升高。此外，许多研究表明，载脂蛋白B100和A1（Apo B100和Apo A1）分别是LDL和高密度脂蛋白（HDL）的相应蛋白质成分，是筛查CAD的更敏感标记。目标：为了确定2型糖尿病患者中Apo A1和Apo B100以及血清MDA的浓度，并研究它们之间的相关性。材料与方法：对75名2型糖尿病患者和75名糖尿病患者进行了病例对照研究健康对照。使用社会科学统计软件包（SPSS）23.0版确定，比较和分析空腹血糖，糖化血红蛋白，空腹血脂谱以及Apo A1，Apo B100和MDA作为脂质过氧化的标志物。结果：糖尿病患者血清甘油三酸酯，Apo B100和MDA的含量明显较高，而HDL和Apo A1的含量则明显较低。在糖尿病患者中，Apo B100 / Apo A1比率也较高，与HbA1c（r = 0.515）和MDA（r = 0.819）呈强正相关。两组中总胆固醇和低密度脂蛋白的水平相当。结论：糖尿病与血脂异常和氧化应激有关。血糖控制不良与氧化损伤增加有关，氧化损伤促进微血管并发症的发展。因此，Apo A1，Apo B100和血清MDA可作为DM管理中的附加参数，因为它们可帮助CAD的早期诊断和预防。

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