...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Factors Associated with Severe Sepsis or Septic Shock in Patients with Gram Negative Bacteraemia: An Observational Cohort Study
【24h】

Factors Associated with Severe Sepsis or Septic Shock in Patients with Gram Negative Bacteraemia: An Observational Cohort Study

机译：革兰氏阴性菌血症患者严重脓毒症或脓毒性休克的相关因素：一项观察性队列研究

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Sepsis is a systemic, host response to infection that progresses from sepsis to severe sepsis to septic shock. Severe sepsis carries significant morbidity and mortality. In the presence of individual risk factors such as old age, diabetes mellitus, chronic liver and renal disease, the death rate remains high despite treatment with antimicrobial agents.Aim: To determine the factors associated with severe sepsis or septic shock and to identify the factors influencing the mortality among patients with gram-negative bacteraemia.Materials and Methods: In this observational cohort study, 219 patients with gram-negative bacteraemia were screened for the presence of sepsis, severe sepsis and septic shock and detailed characteristics of the patients were analysed using independent sample t-test, chi-square test and logistic regression.Results: Among 219 patients with gram-negative bacteraemia, 43 (19.6%) were as classified as severe sepsis, 69 (31.5%) as septic shock and the remaining 107 (48.9%) as only sepsis according to clinical criteria. Diabetes mellitus (p-value=0.006), chronic liver disease (p-value=0.001), presence of urinary catheter (p-value 4 was significant (p-value <0.001) for development of severe sepsis and septic shock and mortality was higher in those with high scores. (p-value <0.0001).Conclusion: The present findings suggest that diabetes mellitus, chronic liver disease, indwelling urinary catheter and organisms other than E. coli are important risk factors for the development of severe sepsis or septic shock. Patients with higher Pitt bacteraemia score may have higher risk of death.
机译：败血症是宿主对感染的系统性，宿主反应，从败血症发展为严重的败血症再到败血性休克。严重的脓毒症具有很高的发病率和死亡率。在存在诸如老年人，糖尿病，慢性肝和肾疾病等个人危险因素的情况下，尽管使用了抗菌药物治疗，死亡率仍然很高。目的：确定与严重败血症或败血性休克相关的因素，并找出影响革兰氏阴性菌血症患者死亡率的因素。材料与方法：在这项观察性队列研究中，对219例革兰氏阴性菌血症患者进行了败血症，严重败血症和败血性休克的筛查，并详细特征分析结果：在219例革兰氏阴性菌血症患者中，有43例（19.6％）被归为严重败血症，69例（31.5％）被归为严重败血症。 ）为败血性休克，其余107（48.9％）根据临床标准仅作为败血症。糖尿病（p值= 0.006），慢性肝病（p值= 0.001），存在导尿管（p值4显着（p值<0.001））导致严重败血症和脓毒性休克和死亡率结论：本研究结果表明，糖尿病，慢性肝病，导尿管留置以及除大肠杆菌外的其他生物是导致糖尿病发生的重要危险因素。严重的败血症或败血性休克：Pitt菌血症评分较高的患者可能有更高的死亡风险。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号