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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Low-dose Misoprostol for Second Trimester Pregnancy Termination in Women with a Prior Caesarean Delivery
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Low-dose Misoprostol for Second Trimester Pregnancy Termination in Women with a Prior Caesarean Delivery

机译：低剂量米索前列醇可在有剖腹产的孕妇中终止妊娠中期

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Termination of Pregnancy (ToP) is an obstetric procedure that can be performed by surgical or medical techniques during the first or second trimester of pregnancy. Medical ToP is recommended in the second trimester owing to its low rate of maternal morbidity. Low-dose misoprostol is an effective option in such cases.Aim: To compare the safety and efficacy of two different vaginal misoprostol regimens for ToP in the second trimester in women with previous Caesarean Deliveries (CDs), against controls.Materials and Methods: This retrospective study was conducted at a university hospital, between January 2005 to December 2014. The study cohort was divided into two groups: history of CD (Group I, n=85) and control (Group II, n=434). The method used for ToP was chosen with respect to history of CD. Four doses of 50 μg misoprostol and 4 doses of 200 μg misoprostol were applied vaginally each day, until regular uterine contractions were observed, to Groups I and II, respectively. Indication of ToP, gestational age at the ToP (weeks), duration from induction to abortion (hours), total misoprostol dose (μg), foetal weight (gram), post-abortion hospitalisation time (day), and any complications were recorded. The Chi-square or Fisher?s-Exact test was used for qualitative data, and the Student?s t-test or Mann-Whitney U-test was used for quantitative data. The p<0.05 was considered significant. Tests were performed using the SPSS statistical package for Windows, version 17 (SPSS, Chicago, Illinois, USA).Results: The success rate of termination was 91.8% (78/85) in Group I and 99.1% (430/434) in Group II (p<0.001). The median induction to abortion interval was 54.08±42.85 hours for Group I and 47.19±31.39 hours in Group II (p=0.371). One case of uterine rupture was recorded in Group I (p=0.164). The incidence of requiring transfusion for haemorrhages was higher in Group I than in Group II (5.9% vs. 1.6%, respectively, p=0.032).Conclusion: Low-dose vaginal misoprostol appears to be a safe and effective procedure for second trimester ToP in women with a history of CD.
机译：妊娠终止（ToP）是一种产科程序，可以在怀孕的前三个月或下三个月通过手术或医学技术进行。由于孕产妇发病率低，建议在孕中期使用医学类TOP。在这种情况下，低剂量米索前列醇是一种有效的选择。目的：比较两种剖宫产分娩（CDs）早产妇女在妊娠中期两种不同的阴道米索前列醇对ToP的安全性和有效性。 >材料与方法：这项回顾性研究于2005年1月至2014年12月在一家大学医院进行。该研究队列分为两组：CD史（I组，n = 85）和对照组（II组，n = 85）。 434）。根据CD的历史选择用于ToP的方法。每天阴道分别向I组和II组阴道施用四剂50μg米索前列醇和4剂200μg米索前列醇，直到观察到规则的子宫收缩。记录ToP，ToP的胎龄（周），从引诱到流产的持续时间（小时），米索前列醇总剂量（μg），胎儿体重（克），流产后住院时间（天）以及所有并发症。卡方检验或Fisher精确检验用于定性数据，学生t检验或Mann-Whitney U检验用于定量数据。 p ＜0.05被认为是显着的。使用Windows版本17的SPSS统计软件包（SPSS，美国伊利诺伊州芝加哥的芝加哥）进行测试。结果：第一组的终止成功率为91.8％（78/85），第一组的终止成功率为99.1％（430 /组434（p <0.001）。第一组的中位诱导流产间隔为54.08±42.85小时，第二组为47.19±31.39小时（p = 0.371）。在第一组中有1例子宫破裂（p = 0.164）。 I组需要输血的出血发生率高于II组（分别为5.9％和1.6％，p = 0.032）。结论：低剂量的阴道米索前列醇似乎是一种安全有效的治疗方法有CD史的女性中晚期ToP。

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