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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Study of Outcomes of Smoking Cessation Interventions in Tuberculosis Patients using Urinary Cotinine Levels
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Study of Outcomes of Smoking Cessation Interventions in Tuberculosis Patients using Urinary Cotinine Levels

机译：用尿可替宁水平研究结核病患者戒烟干预的结果

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In a developing country like India, patients of pulmonary Tuberculosis (TB) form an important subset of individuals requiring smoking cessation counselling and pharmacotherapy. Smoking increases risk of Mycobacterium Tuberculosis (MTB) infection, the risk of progression from infection to disease and the risk of death from TB. Smoking cessation counselling and pharmacological therapy help in improving outcomes of TB treatment, reduce transmission of TB and improve the quality of life of TB patients.Aim: To assess the effectiveness of smoking cessation counselling combined with bupropion in patients of pulmonary tuberculosis using urinary cotinine levels. The study was a prospective interventional study, carried out at Out Patient Department (OPD) and inpatient setting of a tertiary care respiratory centre in an urban setting between the period of July 2016 to June 2019.Materials and Methods: Seventy-six pulmonary TB patients who were active tobacco smokers and fulfilled the inclusion criteria were recruited for the study. Subjects received smoking cessation counselling for one year along with tab bupropion for first three months. Effectiveness of the interventions was assessed by regular follow-up visits at one month, three months, six months and twelve months post-initiation of therapy. Data analysis was done by using SPSS version 17.0 and Microsoft Excel. Chi-square test was used and p-value <0.05 was considered significant.Results: A total of 63 subjects were eligible for statistical analysis. Abstinence rates with bupropion and smoking cessation counselling at 12 months of follow-up were found to be 15.9%. Abstinence rates were found to be higher in patients with low nicotine dependence.Conclusion: The study will provide data on smoking cessation with counselling and bupropion in Indian patients suffering from pulmonary TB.
机译：在印度这样的发展中国家，肺结核（TB）患者是需要戒烟咨询和药物治疗的重要人群。吸烟会增加结核分枝杆菌（MTB）感染的风险，从感染演变为疾病的风险以及结核病导致死亡的风险。戒烟咨询和药物治疗有助于改善结核病治疗的结果，减少结核病的传播并改善结核病患者的生活质量。目的：评估联合使用烟酸安非他酮的戒烟咨询对肺结核患者的有效性。尿可替宁水平。该研究是一项前瞻性干预研究，于2016年7月至2019年6月期间在门诊部（OPD）和市区三级护理呼吸中心的住院患者中进行。材料与方法：76招募了活跃吸烟者并且符合纳入标准的肺结核患者。受试者接受了为期一年的戒烟咨询以及安非他酮的前三个月的咨询。通过在治疗开始后的一个月，三个月，六个月和十二个月进行定期随访，评估干预措施的有效性。使用SPSS 17.0版和Microsoft Excel完成数据分析。使用卡方检验，p值<0.05被认为是显着的。结果：共有63名受试者符合统计学分析的条件。在随访的12个月中，使用安非他酮和戒烟咨询的戒酒率为15.9％。发现对尼古丁依赖性低的患者的戒酒率更高。结论：该研究将为印度肺结核患者提供咨询和安非他酮戒烟的数据。

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