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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers??An Immunohistochemical Study
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Cyclin D1 Gene Expression in Oral Mucosa of Tobacco Chewers??An Immunohistochemical Study

机译：咀嚼剂口腔黏膜中Cyclin D1基因表达的免疫组织化学研究

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Objective: The objective of the present study was to evaluate the expression of cyclin D1 in normal oral mucosa of both non tobacco habituated and tobacco habituated individuals histologically and also compare and correlate cyclin D1 expression with histopathologically confirmed cases of oral squamous cell carcinomas.Study Design: The present study involved 20 cases of tobacco habituated individuals with normal oral mucosal tissue and 20 histopathologically confirmed cases of squamous cells carcinomas. Twelve cases of non tobacco habituated individuals served as control group. Chi-square analysis was used to determine statistical significance.Results: Fifty percent of control cases, 70% of squamous cell carcinoma cases and 80% of tobacco habituated individuals of clinically normal mucosa showed cyclin D1 positivity. Thirteen cases with tobacco chewing habit, with clinically normal mucosa, showed dysplasia, out of which seven were mildly dysplastic and six were moderately dysplastic. A larger percentage of cyclin D1 expression was observed in lower grade dysplasias (53.8%) than higher grade dysplasias (46.1%). However statistical analysis showed no significant association between groups. Chi-square value was <7.82 for p=0.05.Conclusion: The finding of cyclin D1 expression in 80% of tobacco users with clinically normal mucosa indicates that the mutation of cyclin D1 occurs early, even before clinical changes are apparent. This finding appears to be previously unreported. The presence of dysplasia in the same group and cyclin D1 expression in 84.6% of dysplastic cases show that the patients are susceptible for further changes, including progression to higher grades of dysplasia and development of carcinoma. Relatively lower expression of cyclin D1 positivity (70%), in oral cancer patients, when compared with tobacco users with clinically normal mucosa (80%) is indicative of increased traverse of the cell through the cell cycle, which may occur early in tumor progression. Cyclin D1 immunoreactivity was detected in all the three study groups.
机译：目的：本研究的目的是通过组织学评估非吸烟习惯和烟草习惯个体正常口​​腔黏膜中cyclin D1的表达，并将cyclin D1的表达与组织病理学确诊的口腔鳞状细胞癌病例进行比较和关联。 ：本研究涉及20例具有正常口腔粘膜组织的烟草适应性个体和20例经病理组织学证实的鳞状细胞癌病例。对照组为十二例非吸烟习惯性个体。结果：结果：临床正常黏膜正常对照者中有50％，鳞状细胞癌病例中有70％，鳞状细胞癌吸烟者中有80％具有周期蛋白D1阳性。 13例具有咀嚼烟草习惯并具有正常黏膜临床表现的异常增生，其中7例为轻度异常增生，6例为中度异常增生。与低度发育不良（46.1％）相比，在低度发育不良（53.8％）中观察到更大的细胞周期蛋白D1表达百分比。但是，统计分析表明，各组之间无显着关联。卡方值＜7.82（p = 0.05）。结论：在临床黏膜正常的烟草使用者中，有80％的吸烟者发现了cyclin D1的表达，表明cyclin D1的突变发生得早，甚至在临床变化不明显之前。此发现以前未报告过。同一组中存在异型增生，并且在84.6％的异型增生病例中cyclin D1表达表明，患者易于发生进一步的变化，包括进展为更高等级的异型增生和癌变。与临床上黏膜正常的烟草使用者相比，口腔癌患者中细胞周期蛋白D1阳性表达的相对较低（70％），这表明细胞遍历整个细胞周期可能增加，在肿瘤进展早期。在所有三个研究组中均检测到细胞周期蛋白D1的免疫反应性。

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