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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Estimation of Recent Transmission of Mycobacterium Tuberculosis Strains among Iranian and Afghan Immigrants: A Cluster-Based Study
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Estimation of Recent Transmission of Mycobacterium Tuberculosis Strains among Iranian and Afghan Immigrants: A Cluster-Based Study

机译：估计的伊朗和阿富汗移民中结核分支杆菌菌株的近期传播：基于聚类的研究。

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Background: Iran has extended borders with high-TB burden countries (Afghanistan and Pakistan) and immigrations of these populations influences TB distribution in the region and threatens the control strategies. The aim of this study was to evaluate the extent of recent TB transmission among Iranian and Afghan cases.Materials and Methods: Spoligotyping and 15-locus variable number tandem repeat (VNTR) typing were applied to genotype 102 MTB isolates (2009 to 2010). Phylogenetic relationships were analysed by two methods: a cluster-graph method and a minimum spanning tree (MST) method. Furthermore, evaluation of recent TB transmission was assessed with three indices including, RTIn, RTIn-1 and TMI.Results: Using molecular typing, 35 different spoligotypes were detected among the studied isolates. Seventy seven cases (75.4%) were distributed into 10 clusters and the remaining 25 (24.5%) isolates had a unique pattern. The cluster sizes also ranged from 2 to 21 isolates. The most frequent spoligotype in our populations belong to Haarlem (n=30, 29.4%) followed by CAS (n= 29, 28.4%) and Beijing (n=16, 15.6%) lineages. The used indices give the following values: RTIn = 0.75, RTIn-1 = 0.65 and TMI = 0.24.Conclusion: The low rate of TB transmission in our findings (24%) showed that the mode of TB transmission in Iran is mostly associated with reactivation of a previous TB infection and that recently a transmitted disease has a minor role. However, the increasing incidence of the intra-community transmission in recent years highlights the need for establishing new strategies for control of TB.
机译：背景：伊朗扩大了与高结核病负担国家（阿富汗和巴基斯坦）的边界，这些人口的移民影响了该地区的结核病分布并威胁到控制策略。本研究的目的是评估伊朗人和阿富汗人之间最近的结核病传播程度。材料与方法：将Spoligotyping和15位可变数目串联重复序列（VNTR）分型应用于基因型102个MTB分离株（2009年至2010年）。系统发育关系通过两种方法进行分析：聚类图方法和最小生成树（MST）方法。此外，还通过RTIn，RTIn-1和TMI三个指标对最近的结核病传播进行了评估。结果：使用分子分型，在研究的分离株中检测到35种不同的嗜血菌型。 77个病例（75.4％）被分为10个类群，其余25个（24.5％）分离株具有独特的模式。簇的大小也从2到21个分离株不等。我们人口中最常见的血吸虫型是哈莱姆（n = 30，29.4％），其次是CAS（n = 29，28.4％）和北京（n = 16，15.6％）。使用的指数给出以下值：RTIn = 0.75，RTIn-1 = 0.65和TMI = 0.24。结论：我们发现的结核病传播率低（24％）表明，伊朗的结核病传播方式主要与重新激活以前的结核病感染和最近传播的疾病的作用很小。但是，近年来社区内部传播的发生率不断增加，这凸显了建立控制结核病新策略的必要性。

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