• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >To Study the Efficacy of Difluprednate Ophthalmic Emulsion and Prednisolone Acetate Ophthalmic Suspension on Post-operative Inflammation in Cataract Surgery
【24h】

To Study the Efficacy of Difluprednate Ophthalmic Emulsion and Prednisolone Acetate Ophthalmic Suspension on Post-operative Inflammation in Cataract Surgery

机译：研究双氟泼特钠眼用乳剂和醋酸泼尼松龙眼用混悬剂对白内障手术后炎症的疗效

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Introduction: Senile cataract is the most common cause of visual impairment. Removal of cataract and implantation of intraocular lens implantation (IOL) is the main surgical approach for cataract. The major block in quick visual rehabilitation of the patient is post-operative inflammation. To limit post-operative inflammation corticosteroids drugs are used in routine prophylactically. Topical prednisolone acetate 1% and betamethasone 0.1% remain gold standard to control post-operative inflammation but newer drugs like difluprednate, loteprednol are also effective in controlling inflammation.Aim: To study the efficacy of difluprednate ophthalmic emulsion and prednisolone acetate ophthalmic suspension on Post-operative inflammation in cataract surgery (clear corneal phacoemulsification with foldable IOL).Materials and Methods: This study was carried out on 100 patients having visually significant cataract requiring surgery, clear corneal phacoemulsification with foldable intraocular lens implantation was done in all patients. Patients were randomly divided into two groups. In group A topical 1% prednisolone acetate ophthalmic suspension was administered six times a day Post-operatively. In group B 0.05% difluprednate ophthalmic emulsion was administered six times a day post-operatively. Efficacy of drug was evaluated in terms of decrease in ocular pain, anterior chamber reaction in the form of aqueous cells and flare and final visual acuity at 4 weeks.Results: In this study, 92% of patients in group A and 90% of patients in group B had BCVA 6/6. None of the patients in group A had ocular pain. In group B, 96% patients had no ocular pain. Remaining 4% had mild discomfort but required no medication. 98% of patients in group A and 100% of patients in group B presented with clearance of aqueous cells at the end of study. Only 2% of patients in group A had showed cell score (±).Conclusion: Though prednisolone acetate has been the gold standard anti inflammatory agent, 0.05% Difluprednate ophthalmic emulsion is equally effective in treatment of post-operative inflammation. Difluprednate have added an advantage of uniform drug dosage and absence of harmful preservative.
机译：简介：老年性白内障是视力障碍的最常见原因。白内障的去除和人工晶状体植入术（IOL）是白内障的主要手术方法。患者快速视觉康复的主要障碍是术后炎症。为了限制术后炎症，在常规预防中使用皮质类固醇药物。 1％的醋酸泼尼松龙和0.1％的倍他米松仍是控制术后炎症的金标准，但较新的药物如双氟泼尼，洛替泼诺也能有效控制炎症。目的：研究双氟泼尼酯眼用乳液和醋酸泼尼松龙眼用混悬液对术后的疗效白内障手术中的手术性炎症（可折叠IOL进行清晰的角膜超声乳化术）。材料与方法：本研究针对100例需要手术的具有明显视觉白内障的患者，所有患者均进行了透明角膜超声乳化术及可折叠人工晶状体植入术。将患者随机分为两组。在A组中，术后一天六次局部使用1％醋酸泼尼松龙眼用混悬液。在B组中，术后一天六次给予0.05％的二氟泼尼酯眼用乳剂。在4周时根据眼痛的减轻，水细胞和耀斑形式的前房反应以及最终视敏度评估了药物的疗效。结果：在这项研究中，A组的患者为92％，A组的患者为90％ B组的BCVA为6/6。 A组患者均无眼痛。 B组中96％的患者没有眼痛。其余4％有轻度不适感，但无需药物治疗。在研究结束时，A组中98％的患者和B组中100％的患者表现出水细胞清除。结论：尽管醋酸泼尼松龙已成为金标准抗炎药，但0.05％的双氟泼特钠眼用乳剂对术后炎症反应同样有效。双氟泼尼特增加了药物剂量均匀且不含有害防腐剂的优势。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号