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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Association between Periodontal Status, Serum Lipid Levels, Lipoprotein Associated Phosholipase A2 (Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls ZC17-ZC21
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The Association between Periodontal Status, Serum Lipid Levels, Lipoprotein Associated Phosholipase A2 (Lp-PLA2) in Chronic Periodontitis Subjects and Healthy Controls ZC17-ZC21

机译：慢性牙周炎受试者与健康对照者ZC17-ZC21的牙周状态，血清脂质水平，脂蛋白相关的磷脂酶A2（Lp-PLA2）之间的关联

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Introduction: Lipoprotein associated phospholipase A2 (Lp-PLA2) has been explored as a potential biomarker for Cardiovascular Disease (CVD). The human Lp-PLA2 is a serine-dependent, Ca2+- independent enzyme. It gives way to oxidised free fatty acids and lysophosphatidyl choline by hydrolysing oxidised phospholipids, that leads to smooth muscle cell apoptosis, inflammatory cell chemotaxis and endothelial cell dysfunction in CVD. Owing to its role in inflammation, it may influence the development and progression of periodontitis as well.Aim: To compare the demographic variables, Gingival Index(GI), Bleeding On Probing (BOP) , Probing Pocket Depth (PPD), and Clinical Attachment Level (CAL) with serum lipid profile and Lp-PLA2 level in Chronic Periodontitis (CP) subjects.Materials and Methods: A total of 75 subjects were selected and divided into three groups; based on the inclusion and exclusion criteria: Group I - 25 subjects with severe generalized CP with CAL = 5 mm in more than 30% of sites. Group II - 25 subjects with moderate generalized CD with clinical CAL 3 mm-4 mm in more than 30% of sites. Group III- 25 systemically and periodontally healthy volunteers who served as control. Clinical parameters such as Plaque Index (PI), BOP, Probing Depth (PD) and CAL , lipid profile such as Total Cholesterol (TC), Triglyceride (TG), High density Lipoprotein (HDL), Low Density Lipoprotein (LDL), Very Low Density Lipoprotein (VLDL) as well as Lp-PLA2 were assessed. One-way ANOVA and Tukey's Post-hoc test were used for data analysis.Results: Age was higher in Group I and II when compared to Group III. Group II showed a significant correlation between PI and LDL. In Group III, lower PI was significantly correlated with high HDL and low LDL and BOP was positively correlated with TG and HDL. A significant association of Lp-PLA2 was found to be higher with increase in the TG and VLDL level in Group I and Group II when compared to Group III.Conclusion: The study concluded that Lp-PLA2, TG and VLDL already being a predictor biomarker for atherosclerotic disease can be an inflammatory marker for periodontitis.
机译：简介：脂蛋白相关的磷脂酶A2（Lp-PLA2）已被研究为心血管疾病（CVD）的潜在生物标记。人Lp-PLA2是丝氨酸依赖性，Ca2 +依赖性酶。它通过水解氧化的磷脂而取代了氧化的游离脂肪酸和溶血磷脂酰胆碱，导致平滑肌细胞凋亡，炎性细胞趋化性和CVD中的内皮细胞功能障碍。由于其在炎症中的作用，它也可能影响牙周炎的发生和发展。目的：比较人口统计学变量，牙龈指数（GI），探查出血（BOP），探查口袋深度（PPD）和临床依从性慢性牙周炎（CP）受试者的血脂水平（CAL）和Lp-PLA2水平。材料与方法：总共选择了75名受试者，分为三组;每组75名。根据纳入和排除标准：第I组-25个受试者中超过30％的部位患有严重的全身性CP，CAL = 5 mm。第二组-25名中度广义CD患者，临床CAL在3％至4 mm，超过30％的部位。第III-25组系统和牙周健康的志愿者作为对照。临床参数，例如菌斑指数（PI），BOP，探测深度（PD）和CAL，脂质谱，例如总胆固醇（TC），甘油三酸酯（TG），高密度脂蛋白（HDL），低密度脂蛋白（LDL），非常评估了低密度脂蛋白（VLDL）以及Lp-PLA2。使用单向方差分析和Tukey的事后检验进行数据分析。结果：与第三组相比，第一和第二组的年龄较高。第二组显示PI和LDL之间存在显着相关性。在第三组中，较低的PI与高HDL和低LDL显着相关，而BOP与TG和HDL正相关。与第三组相比，第一组和第二组中Lp-PLA2的显着相关性随TG和VLDL水平的升高而升高。动脉粥样硬化疾病可能是牙周炎的炎症标志物。

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