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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Understanding Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Critical Update in Development of New Approaches
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Understanding Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma: A Critical Update in Development of New Approaches

机译：了解头颈部鳞状细胞癌中的癌干细胞：新方法开发中的重要更新。

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Cancer Stem Cells (CSCs) have an important role in Head and Neck Squamous Cell Carcinoma (HNSCC). HNSCC is considered as one of the major health problems throughout the world. These self-renewing cells are responsible for resistance to conventional anti-cancer therapy. CSCs have the ability of cancer recurrence; metastasis and can form a heterogeneous tumour. The idea of 'CSCs' has led the scientific community to a new era in the field of research and possibly effective treatment modalities for cancer in the future. This paper aims primarily to review the recent advancements made in the use of stem cells in the treatment of cancer. Secondly, this review presents a discussion on the consideration of CSCs being the backbone in the development of cancer and, precisely the role played by the CSCs in carcinogenesis and its outcome leading to development of possible cancer treatment in the future. Medical databases including Pubmed Central, Google Scholar, Scopus, Copernicus, Science Direct, etc., were used to find all relevant articles related to HNSCC and its relation with CSCs, various mechanisms and therapeutic approaches. Various therapeutic approaches have been employed for the management of HNSCC such as surgical method, chemotherapies and radiotherapies and combinations or formulations of different drugs, but in most cases complete cure has been a failure. This is mostly because the CSCs escape such therapies. However, recent developments have led to the use of targeted therapy such as targeting cell surface markers or signalling pathways, targeting micro environment or blocking epithelial mesenchymal transition, immunotherapy and other approaches as well, leading to the complete eradication of CSCs in HNSCC successfully. Thus, this review presents a better understanding of CSCs and its mechanism of action for development of new treatment modalities.
机译：癌症干细胞（CSC）在头颈部鳞状细胞癌（HNSCC）中具有重要作用。 HNSCC被认为是全世界主要的健康问题之一。这些自我更新的细胞负责抵抗常规的抗癌治疗。 CSC具有癌症复发的能力;转移并可以形成异质性肿瘤。 “ CSCs”的概念已将科学界带入了研究领域的新纪元，并可能在未来为癌症提供有效的治疗方式。本文的主要目的是回顾使用干细胞治疗癌症的最新进展。其次，本文将就CSCs在癌症发展中的骨干作用的考虑，以及CSCs在致癌作用中的作用及其导致未来癌症治疗发展的结果进行讨论。医学数据库包括Pubmed Central，Google Scholar，Scopus，Copernicus，Science Direct等，用于查找与HNSCC及其与CSCs，各种机制和治疗方法的关系的所有相关文章。已经采用了各种治疗方法来治疗HNSCC，例如手术方法，化学疗法和放射疗法以及不同药物的组合或制剂，但是在大多数情况下，完全治愈是失败的。这主要是因为CSC逃脱了这种疗法。然而，最近的发展已导致靶向疗法的使用，例如靶向细胞表面标志物或信号通路，靶向微环境或阻断上皮间质转化，免疫疗法和其他方法，从而成功地彻底根除了HNSCC中的CSC。因此，本综述对CSC及其开发新治疗方式的作用机制有更好的了解。

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