...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Analysis of Dexmedetomidine and Propofol Based Sedation Regimens on Anaesthetic Requirements in Cardiac Surgery with On-pump Cardiopulmonary Bypass
【24h】

Comparative Analysis of Dexmedetomidine and Propofol Based Sedation Regimens on Anaesthetic Requirements in Cardiac Surgery with On-pump Cardiopulmonary Bypass

机译：右美托咪定和丙泊酚镇静方案在体外循环泵心脏手术中麻醉要求的比较分析

获取原文
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Dexmedetomidine is a selective a2-agonist that has been successfully used as an anaesthetic adjuvant in cardiac surgery.Aim: To evaluate the effect of dexmedetomidine on intraoperative requirements of isoflurane and opioids for maintenance of anaesthesia during On-pump cardiac surgery and compare the anaesthesia sparing effect with that of propofol.Materials and Methods: This was a randomised, double blind observational study. Morphine consumption and minimum alveolar concentration of isoflurane was compared among 60 patients planned for elective open heart surgeries who were randomised to receive either dexmedetomidine (1 μg/kg bolus over 10 minutes followed by infusion of 0.2 to 0.6 μg/kg/hour) or propofol (0.25-1 mg/kg/hour) throughout the intraoperative period till skin closure. The drug infusions were titrated to target Bispectral Index (BIS) score of 40-60. BIS scores and minimum alveolar concentration of isoflurane were recorded at predetermined intervals during surgery. Total dose of morphine used was also recorded. Statistical analysis was carried out using analysis of variance, Chi-square test, Student?s t-test and Mann?Whitney U test.Results: BIS scores were significantly lower in dexmedetomidine group (p<0.05). Total dose of morphine and minimum alveolar concentration of isoflurane were significantly lower in dexmedetomidine group (p<0.05).Conclusion: From the results we concluded that intraoperatively administered dexmedetomidine during On-pump cardiac surgery has specific analgesic properties and decreases intraoperative anaesthetic requirement. Thus, dexmedetomidine has significant opioid and anaesthetic sparing property.
机译：右美托咪定是一种选择性的a2激动剂，已成功用作心脏外科手术中的麻醉佐剂。目的：评估右美托咪定对异氟烷和阿片类药物在术中心脏维持手术期间维持麻醉的需求，并进行比较材料与方法：这是一项随机，双盲的观察性研究。比较了60位计划进行择期开放性心脏手术的患者的吗啡消耗量和异氟烷的最低肺泡浓度，这些患者随机接受右美托咪定（10分钟内推注1μg/ kg推注，然后输注0.2至0.6μg/ kg /小时）或丙泊酚（0.25-1 mg / kg / hour）在整个手术期间直至皮肤闭合。将药物输注滴定至40-60的目标双光谱指数（BIS）分数。在手术期间以预定间隔记录BIS分数和异氟醚的最低肺泡浓度。还记录了吗啡的总剂量。使用方差分析，卡方检验，Student's t检验和Mann？Whitney U检验进行统计学分析。结果：右美托咪定组的BIS评分显着降低（p <0.05）。右美托咪定组的吗啡总剂量和异氟烷的最低肺泡浓度均显着降低（p <0.05）。结论：从结果中我们得出结论，在泵上心脏手术中术中给予右美托咪定具有特定的镇痛作用并降低术中麻醉剂需求。因此，右美托咪定具有显着的阿片样物质和麻醉剂保留性质。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号