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首页> 外文期刊>Journal of Clinical and Diagnostic Research >The Potential Curative and Prophylactic Effects of Grape Seed Extract on Aspirin Induced Gastric Ulcer in Adult Male Albino Rats
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The Potential Curative and Prophylactic Effects of Grape Seed Extract on Aspirin Induced Gastric Ulcer in Adult Male Albino Rats

机译：葡萄籽提取物对阿司匹林诱导的成年雄性白化病大鼠胃溃疡的潜在疗效和预防作用

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Aspirin {Acetyl Salicylic Acid (ASA)} is a potent Nonsteroidal Anti-Inflammatory Drug (NSAID). Gastric ulcer associated with the use of aspirin is a major problem. Grape Seed Extract (GSE), has been shown to produce effective antioxidant effects.Aim: To evaluate the effect of grape seed extract on gastric ulcer induced by aspirin.Materials and Methods: Fifty adult rats were classified into: Group I (control group); Group II (GSE group), which received a single dose of GSE (250 mg/kg/day) by gavage for 10 days; Group III (Gastric ulcer group), which received (300 mg/kg) of aspirin by gavage and Group IV (Prophylactic group), which received GSE (250 mg/kg/day) by gavage for 10 days, one hour after administration of the last dose each rat received a single dose of aspirin (300 mg/kg) by gavage, Group V (Curative group), which received a single oral dose (300 mg/kg) of aspirin, five hours after administration of aspirin each rat received an oral dose (250 mg/kg) of GSE for 10 days. At the end of the study, the rats were anaesthetized and the stomach from all groups were extracted and examined. ANOVA test followed by a post-hoc test (LSD) were employed to compare the results of studied animal groups.Results: The gastric tissue of group III revealed extensive mucosal erosions and sloughing of gastric glands. GSE administration in the prophylactic group resulted in intact mucosa with minimal inflammatory infiltration while sloughing of gastric glands was still observed in some areas in the curative group. Significant increase in the percentage of iNOS and MDA level was found in Group III compared to control group, while significant decrease of iNOS and MDA level was noticed in Group IV and Group V as compared to Group III.Conclusion: Results of the current study revealed that administration of GSE before induction of gastric ulcer could greatly ameliorate the condition than after the induction of the ulcer.an.
机译：阿司匹林{乙酰水杨酸（ASA）}是一种有效的非甾体类抗炎药（NSAID）。与使用阿司匹林有关的胃溃疡是一个主要问题。葡萄籽提取物（GSE）已显示出有效的抗氧化作用。目的：评估葡萄籽提取物对阿司匹林诱导的胃溃疡的作用。材料与方法：五十只成年大鼠分为：第一组（对照组）;第二组（GSE组），通过强饲法接受单剂GSE（250 mg / kg /天），持续10天;第三组（胃溃疡组）通过灌胃法接受阿司匹林（300 mg / kg），第四组（预防组）通过灌胃法接受GSE（250 mg / kg /天），持续10天，给药后一小时每只大鼠的最后一次剂量通过灌胃法向单组服用阿司匹林（300 mg / kg），第V组（治疗组），在每只大鼠服用阿司匹林5小时后接受单次口服剂量（300 mg / kg）阿司匹林接受GSE口服剂量（250 mg / kg），持续10天。在研究结束时，麻醉大鼠并提取和检查所有组的胃。 bNOVA结果：III组的胃组织显示出广泛的粘膜侵蚀和胃腺塌陷。采用ANOVA测试，然后采用事后测试（LSD）来比较研究的动物组的结果。预防组使用GSE可使粘膜完整，炎症浸润最少，而治疗组的某些区域仍观察到胃腺脱落。与对照组相比，第三组的iNOS和MDA水平百分比显着增加，而第四组和第五组的iNOS和MDA水平则显着低于第三组。结论：目前的研究表明，与诱发胃溃疡相比，在诱发胃溃疡之前给予GSE可以大大改善病情。

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