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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Results Of Two Multicentric, Comparative, Randomized, Parallel Group Clinical Trials To Evaluate The Efficacy And Safety Of Dexketoprofen Trometamol In The Treatment Of Dental Pain And Dysmenorrhoea In Indian Patients
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Results Of Two Multicentric, Comparative, Randomized, Parallel Group Clinical Trials To Evaluate The Efficacy And Safety Of Dexketoprofen Trometamol In The Treatment Of Dental Pain And Dysmenorrhoea In Indian Patients

机译：两项多中心，比较，随机，平行分组的临床试验的结果，以评估右旋苯丙酸曲美他莫在印度患者牙痛和痛经中的疗效和安全性

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Background: Dexketoprofen is the active enantiomer of the popular NSAID Ketoprofen which is a 50:50 mixture of S (+) and R (-) enantiomers. Aims: To demonstrate therapeutic efficacy and safety of Dexketoprofen 25 mg as compared to Ketoprofen 50 mg in patients undergoing dental surgery and in patients with dysmenorrhoea.Study Design: Multicentric, comparative, randomized, parallel group studies. Materials and Methods: Out patients undergoing third molar extraction were randomized to receive either Dexketoprofen or Ketoprofen. In a separate study, patients with dysmenorrhoea were randomized into similar two groups. Pain intensity as recorded on Visual Analogue Scale before therapy and at regular intervals after therapy was quantified and statistically analysed.Materials and Methods: Out patients undergoing third molar extraction were randomized to receive either Dexketoprofen or Ketoprofen. In a separate study, patients with dysmenorrhoea were randomized into similar two groups. Pain intensity as recorded on Visual Analogue Scale before therapy and at regular intervals after therapy was quantified and statistically analysed. Results: In both the studies, the groups were comparable in demographics and baseline pain intensity. Dexketoprofen was as effective as Ketoprofen in relieving pain during menstruation. In case of dental pain, Dexketoprofen provided early onset of statistically significant analgesia as compared to Ketoprofen. Conclusions: Dexketoprofen (25mg) is as effective as Ketoprofen (50mg) in the treatment of dysmenorrhoea and is a faster and equally safe analgesic in the treatment of acute pain of dental surgery.
机译：背景：右酮洛芬是流行的NSAID酮洛芬的活性对映体，它是S（+）和R（-）对映体的50:50混合物。目的：证明在进行牙科手术和痛经的患者中，右酮洛芬25 mg与酮洛芬50 mg的治疗效果和安全性。研究设计：多中心，对比，随机，平行分组研究。材料和方法：将接受第三磨牙拔除的患者随机接受右旋酮洛芬或酮洛芬治疗。在另一项研究中，痛经患者被随机分为两组。量化并统计分析治疗前和治疗后定期按视觉模拟量表记录的疼痛强度。材料和方法：将接受第三磨牙拔除的患者随机接受右旋酮洛芬或酮洛芬。在另一项研究中，痛经患者被随机分为两组。量化并统计分析治疗前和治疗后定期记录的视觉模拟量表上的疼痛强度。结果：在两项研究中，两组的人口统计学和基线疼痛强度均相当。右酮洛芬与酮洛芬在缓解月经期疼痛方面同样有效。在发生牙痛的情况下，与酮洛芬相比，右酮洛芬提供了统计学上显着的止痛药。结论：右酮洛芬（25mg）在治疗痛经方面与酮洛芬（50mg）一样有效，并且在牙科手术的急性疼痛治疗中是一种更快，同样安全的镇痛药。

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