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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Hepatoprotective Activity Of Aqueous Extract Of Fruit Pulp Of Cassia Fistula (AFCF) Against Carbon Tetrachloride (CCL4) Induced Liver Damage In Albino Rats.
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Hepatoprotective Activity Of Aqueous Extract Of Fruit Pulp Of Cassia Fistula (AFCF) Against Carbon Tetrachloride (CCL4) Induced Liver Damage In Albino Rats.

机译：决明子瘘（AFCF）果肉水提取物对四氯化碳（CCL4）诱导的白化病大鼠肝损伤的保护作用。

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Objective: To evaluate Hepatoprotective activity of aqueous extract of fruit pulp of Cassia fistula (AFCF) against Carbon tetrachloride (CCL4) induced liver damage in albino rats and compared to standard drug silymarin.Materials And Methods: Healthy albino rats of either sex weighing 150-200gm were divided into four groups of six animals each.Group A (Normal control) ? 3% gum acacia (2ml/kg/day) orally and olive oil s.c.Group B (Exp.Control) ? 3% gum acacia orally and CCL4 and olive oil (1:1 v/v) s.c.Group C (Test) ? AFCF (200mg/kg/day) orally and CCL4 s.c.Group D (Standard) - Silymarin (100mg/kg/day) and CCL4 s.c.Hepatic injury was induced to animals belonging to group B, C and D by giving CCL4 & olive oil mixture s.c on 2nd and 3rd day of experiment. Standard and test drugs were administered for 5 days. Blood samples were collected on 6th day for determination of enzyme markers viz, aspartate transaminase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) and total protein (TP). Histopathological examinations of liver tissues were also performed. Results: One way ANOVA followed by Dunnett?s multiple comparison test were used for statistical analysis. Values of p < 0.01 were considered significant. There was significant (p<0.01) increase in all serum marker enzymes and total bilirubin and significant (p<0.01) decrease in total protein in group B. The AFCF and Silymarin resulted in significant (p<0.01) reduction in serum levels of AST, ALT, ALP, TB and increase in TP as compared to group B. Fatty changes, necrosis and fibrosis were observed in group B on histopathology, while in group C and D it was near normal.Conclusion: As revealed by the study aqueous extract of fruit pulp of Cassia fistula possesses significant hepatoprotective activity.
机译：目的：评价决明子瘘果肉水提取物对四氯化碳（CCL4）引起的白化病大鼠肝损伤的保肝活性，并与标准药物水飞蓟素进行比较。将200gm分为四组，每组六只动物。口服3％的阿拉伯树胶（2ml / kg /天）和橄榄油s.c. B组（Exp.Control）？口服3％的阿拉伯树胶和CCL4和橄榄油（1：1 v / v）s.c. C组（测试）口服AFCF（200mg / kg /天）和CCL4 scD组（标准）-水飞蓟素（100mg / kg /天）和CCL4 sc通过给予CCL4和橄榄油混合物对B，C和D组动物进行肝损伤在实验的第二天和第三天。标准药物和测试药物给药5天。在第6天收集血样，用于测定酶标记，即天冬氨酸转氨酶（AST），丙氨酸氨基转移酶（ALT），碱性磷酸酶（ALP），总胆红素（TB）和总蛋白（TP）。还进行了肝组织的组织病理学检查。结果：采用方差分析和邓尼特多重比较检验的一种方法进行统计分析。 p <0.01的值被认为是显着的。 B组所有血清标志物酶和总胆红素均显着（p <0.01）升高，总蛋白显着降低（p <0.01）。AFCF和水飞蓟素导致AST血清水平显着降低（p <0.01）与B组相比，ALT，ALP，TB和TP升高。在组织病理学上，B组观察到了脂肪变化，坏死和纤维化，而C和D组则接近正常。决明子瘘果肉具有明显的保肝活性。

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