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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Serum Paraoxonase Activity In Normolipidaemic Patients With Acute Myocardial Infarction
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Serum Paraoxonase Activity In Normolipidaemic Patients With Acute Myocardial Infarction

机译：非血脂异常急性心肌梗死患者血清对氧磷酶活性

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Background: Although studies have demonstrated that HDL-C associated paraoxonase is involved in protection of LDL-cholesterol and other lipoproteins from the deleterious effects of oxygen free radicals in ischaemia and reperfusion, there are controversial data on the correlation between paraoxonase activity and the ischaemia process.Aim: The present study was planned to evaluate the paraoxonase activity in patients with acute myocardial infarction (AMI), with normal lipid profile.Setting and Design:Serum paraoxonase activities were determined in 165 normolipidaemic patients diagnosed with AMI, and 165 age and sex matched healthy volunteers served as controls.Material and Methods: Serum Paraoxonase activities were measured by using an enzymatic kit manufactured by the Zeptomatrix Corporation, New York, USA, for AMI patients and controls. Also, the lipid profile was analyzed enzymatically in these subjects.Statistics: The values were expressed as means ± standard deviation (SD), and data from patients and controls was compared by using student?s ?t?-test.Results and Conclusion: Serum paraoxonase activity was significantly decreased in AMI patients as compared to controls (p<0.001). Also, total cholesterol levels, TC/ HDL-C ratio, triglyceride levels, LDL-cholesterol levels, LDL-C/ HDL-C ratio and TG/HDL-C ratio were significantly higher (p<0.001), and HDL-cholesterol levels were significantly lower in AMI patients (p<0.001). No correlation was observed between PON1 activity and HDL-C levels in patients and controls. These findings suggest that decreased paraoxonase activity could be due to increased oxidative stress in AMI.
机译：背景：尽管研究表明HDL-C相关的对氧磷酶参与保护LDL-胆固醇和其他脂蛋白免受缺血和再灌注中氧自由基的有害作用，但有关对氧磷酶活性与缺血过程之间相关性的数据尚有争议目的：本研究旨在评估血脂正常的急性心肌梗死（AMI）患者的对氧磷酶活性。设置与设计：对165名被确诊为AMI的正常血脂病患者以及165个年龄和性别进行了血清对氧磷酶活性的测定。材料和方法：使用美国纽约Zeptomatrix公司生产的酶联试剂盒测定AMI患者和对照组的血清对氧磷酶活性。统计：将这些值表示为平均值±标准差（SD），并通过学生的t检验比较来自患者和对照组的数据。与对照组相比，AMI患者的血清对氧磷酶活性显着降低（p <0.001）。同样，总胆固醇水平，TC / HDL-C比，甘油三酸酯水平，LDL-胆固醇水平，LDL-C / HDL-C比和TG / HDL-C比显着更高（p <0.001），并且HDL-胆固醇水平在AMI患者中明显降低（p <0.001）。在患者和对照中未观察到PON1活性与HDL-C水平之间的相关性。这些发现表明对氧磷酶活性降低可能是由于AMI中氧化应激增加所致。

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