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首页> 外文期刊>Journal of Clinical and Diagnostic Research >NIDDM Antidiabetic Activity Of Saponins Of Momordica Cymbalaria In Streptozotocin-Nicotinamide NIDDM Mice
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NIDDM Antidiabetic Activity Of Saponins Of Momordica Cymbalaria In Streptozotocin-Nicotinamide NIDDM Mice

机译：苦瓜皂苷在链脲菌素-烟酰胺NIDDM小鼠中的抗糖尿病活性

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Objective: To evaluate the Type 2 anti-diabetic activity of saponins obtained from Momordica Cymbalaria in Streptozotocin?Nicotinamide Induced Type 2 diabetic mice.Materials and Method: Type 2 diabetes in BALB/c mice was induced by a single intra-peritoneal injection of Streptozotocin (100 mg/ kg, i.p), 15 min after the intra-peritoneal administration of Nicotinamide (240 mg/ kg, i.p). Hyperglycaemia was confirmed by elevated blood glucose levels determined on day 7 after the injection. The saponin mixture was obtained from the ethanolic extract of Momordica Cymbalaria. Saponins of MC (SMC) 175mg/kg,p.o/30 days and Metformin350mg/kg,p.o/30 days were administered to the Type 2 diabetic mice. At the end of the treatment, their serum was analyzed for glucose, cholesterol, triglycerides and insulin; The pancreas of each mouse was studied to check whether there were any histological changes.Result: Treatment of Type 2 diabetic mice with SMC (175mg/kg, p.o/30 days) and Metformin (350mg/kg,p.o/30 days) produced a significant fall in blood glucose (p<0.001), cholesterol (p<0.001), triglycerides (p<0.001) and an increase in the serum insulin level (p<0.001). Pancreatic islets and beta cells showed an increase in numbers.Conclusion: Saponins of MC have significant Type 2 anti-diabetic activity and the activity may be due to increasing insulin secretion, probably by the regeneration of pancreatic beta cells.
机译：目的：评价苦瓜中皂苷对链脲佐菌素·烟碱酰胺诱导的2型糖尿病小鼠的2型抗糖尿病活性。材料与方法：腹腔内注射链脲佐菌素可诱导BALB / c小鼠2型糖尿病。 （100 mg / kg，腹腔注射），在腹腔内施用烟酰胺（240 mg / kg，腹腔注射）后15分钟。注射后第7天测定的血糖水平升高证实了高血糖症。皂苷混合物获自苦瓜的乙醇提取物。将MC（SMC）175mg / kg，p.o / 30天的皂苷和二甲双胍350mg / kg，p.o / 30天给予2型糖尿病小鼠。治疗结束时，分析他们的血清中的葡萄糖，胆固醇，甘油三酸酯和胰岛素。结果：用SMC（175mg / kg，po / 30天）和二甲双胍（350mg / kg，po / 30天）对2型糖尿病小鼠进行治疗后，对每只小鼠的胰腺进行了组织学检查。血糖（p <0.001），胆固醇（p <0.001），甘油三酸酯（p <0.001）显着下降和血清胰岛素水平升高（p <0.001）。结论：MC的皂苷具有明显的2型抗糖尿病活性，其活性可能归因于胰岛素分泌的增加，可能是胰腺β细胞的再生所致。

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