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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Role Of Free Radicals In Menopausal Distress
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Role Of Free Radicals In Menopausal Distress

机译：自由基在更年期困扰中的作用

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Aim: The aim of the study was to determine the extent of free radical damage in the form of oxidative stress and the antioxidant status in postmenopausal females as compared to premenopausal females.Methods: 100 female subjects (age group 40-50 years) were studied of which 50 were premenopausal and 50 postmenopausal. Oxidative stress was assessed by estimating malondialdehyde (MDA), a lipid peroxidation product in the form of thiobarbituric acid reactive substances. Antioxidants in the form of superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT), vitamin C and E were measured in both the groups. Results: On comparative evaluation, SOD, GPx and vitamin C levels were significantly decreased (p 0.05). Conclusion: Postmenopausal females are exposed to greater risk of oxidative stress as compared to premenopausal females and many of the health problems of menopause may be related to increased oxidative damage.
机译：目的：本研究的目的是确定绝经后女性与绝经前女性相比，氧化应激形式的自由基损伤程度和抗氧化状态。方法：研究了100名女性受试者（40-50岁年龄组）其中50个是绝经前的，50个是绝经后的。通过估计丙二醛（MDA）（一种硫代巴比妥酸反应性物质形式的脂质过氧化产物）来评估氧化应激。两组均测量了超氧化物歧化酶（SOD），谷胱甘肽过氧化物酶（GPx），过氧化氢酶（CAT），维生素C和E形式的抗氧化剂。结果：通过比较评估，SOD，GPx和维生素C水平显着降低（p 0.05）。结论：与绝经前女性相比，绝经后女性面临更大的氧化应激风险，绝经的许多健康问题可能与氧化损伤增加有关。

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