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首页> 外文期刊>Journal of Clinical and Diagnostic Research >OxidativeStress in Diabetic Retinopathy
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OxidativeStress in Diabetic Retinopathy

机译：糖尿病性视网膜病变的氧化应激

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Diabetic retinopathy (DR) is one of the micro-vascular complications of diabetes which leads to blindness among the working age individuals. Chronic hyperglycaemia and dyslipidaemia cause oxidative stress and increase the free radicals. Oxidative stress is one of the important causes in the genesis of microangiopathy. Twenty five patients of Type II Diabetes mellitus (DM) without retinopathy, 50 patients of Type II Diabetes mellitus with non-proliferative diabetic retinopathy and proliferative diabetic retinopathy and 25 normal subjects were included in the study. Fasting plasma glucose (FPG), post prandial plasma glucose (PPPG), glycosylated haemoglobin, lipid profile, plasma malondialdehyde (MDA) and Vitamin C were estimated. The plasma MDA levels were significantly elevated (p< 0.001) and the Vitamin C levels were significantly decreased (p<0.01) as compared to the controls. The study revealed a significant positive association between plasma MDA and both FPG and PPPG (r=0.438, p<0.01, r=0.455, p<0.01 ) , a positive correlation between plasma MDA and HbA1c and also, a positive correlation between plasma MDA and serum triglycerides (r=0.028, p<0.01, r=0.454, p<0.01) and a negative correlation between MDA and Vitamin C (r=0.241, p<0.01). The results suggest that increased lipid peroxidation and a decline in the antioxidant defense mechanisms plays a very important role in the initiation and progression of micro-vascular complications like diabetic retinopathy.
机译：糖尿病性视网膜病（DR）是糖尿病的微血管并发症之一，导致劳动年龄人群失明。慢性高血糖症和血脂异常会引起氧化应激并增加自由基。氧化应激是微血管病发生的重要原因之一。该研究纳入了25例无视网膜病变的II型糖尿病（DM）患者，50例患有非增生性糖尿病视网膜病变和增生性糖尿病性视网膜病变的II型糖尿病患者和25名正常受试者。估计空腹血浆葡萄糖（FPG），餐后血浆葡萄糖（PPPG），糖基化血红蛋白，脂质分布，血浆丙二醛（MDA）和维生素C。与对照组相比，血浆MDA水平显着升高（p <0.001），维生素C水平显着降低（p <0.01）。研究发现血浆MDA与FPG和PPPG之间存在显着正相关（r = 0.438，p <0.01，r = 0.455，p <0.01），血浆MDA与HbA1c之间呈正相关，血浆MDA之间也呈正相关血清甘油三酸酯（r = 0.028，p <0.01，r = 0.454，​​p <0.01），MDA与维生素C呈负相关（r = 0.241，p <0.01）。结果表明，脂质过氧化的增加和抗氧化剂防御机制的降低在诸如糖尿病性视网膜病的微血管并发症的发生和发展中起着非常重要的作用。

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