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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Compliance and Adverse drug Effectsof Antihypertensives in Rural India
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Compliance and Adverse drug Effectsof Antihypertensives in Rural India

机译：印度农村地区降压药的依从性和不良药物作用

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Background: Hypertension is the most prevalent health problem among adult primary care patients, but its recognition and treatment are suboptimal. Adherence and persistence have been studied in patients of hypertension in this study.Material and Methods: 491 patients suffering from hypertension and coming to the OPD of a rural medical hospital in Loni were examined in a prospective study over a year after giving the prescribed antihypertensive medication from Oct 2004 to May 2006.Results: A decrease in blood pressure was observed in patients treated with one pill per day as compared to patients being treated with two and three pills per day. Compliance was significantly better in patients in combination therapy as compared to monotherapy. Cost is an important determinant in deciding compliance.Conclusion: Low dose combination therapy is more effective and is well tolerated than high dose monotherapy. Moreover, the incidence of ADR was observed to be significantly lower with low dose combination therapy in addition to better compliance.
机译：背景：高血压是成人初级保健患者中最普遍的健康问题，但其认识和治疗并不理想。材料与方法：对前瞻性研究中的491名患有高血压并在洛尼市乡村医院的OPD住院的高血压患者，在给予处方降压药物后一年内对其进行了前瞻性研究。结果：从2004年10月至2006年5月，与每天服用2片和3片的患者相比，每天服用1片的患者的血压下降。与单一疗法相比，联合疗法患者的依从性明显更好。费用是决定依从性的重要决定因素。结论：低剂量联合疗法比高剂量单一疗法更有效且耐受性更好。此外，除了更好的依从性外，低剂量联合疗法还观察到ADR的发生率显着降低。

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