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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparative Evaluation of the Efficacy and Side Effects of Imipramine, Sertraline and an Ayurvedic Formulation in Patients of Depression
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Comparative Evaluation of the Efficacy and Side Effects of Imipramine, Sertraline and an Ayurvedic Formulation in Patients of Depression

机译：丙咪嗪，舍曲林和阿育吠陀制剂对抑郁症患者的疗效和副作用的比较评价

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Background: Anti-depressant drugs which are used in the Allopathic system of medicine for the treatment of depression have side effects. Studies which have compared the efficacy and the side effects of Allopathic and Ayurvedic drugs in the treatment of depression have not been reported. Aims: The aim of the present study was to compare the efficacy and the side effects of imipramine and sertraline which are the commonly prescribed drugs in the Allopathic system of medicine for the treatment of depression, with an Ayurvedic formulation. Settings and Design: This study was an open labeled randomized clinical trial which involved 90 depressive patients who were divided into three groups of 30 each, for the administration of imipramine, sertraline, and an Ayurvedic formulation respectively. HAM-D scoring was done and a side effect checklist was also prepared. Materials and Methods: The Ayurvedic formulation consisted of aqueous extracts of Brahmi, Shankhpuship, Malkangni and Jatamansi which were mixed in equal proportions (250 mg each). The Ayurvedic formulation was administered at a dose of 1000 mg orally in two divided doses; and imipramine and sertraline were administered at a dose of 150 mg each per day, to separate the groups of patients. The persons who abided by the inclusion and exclusion criteria were selected randomly. The effect of the treatments on the treated patients was repeatedly assessed at a continuous interval of two weeks for three months. Results: The Ayurvedic formulation had negligible side effects and it was found to be effective at par with imipramine and sertraline at the end of three months. Conclusions: The Ayurvedic formulation was found to be better as compared to imipramine and sertraline for the treatment of patients with mild to moderate depression, due to its lesser side effects.
机译：背景：用于治疗抑郁症的同种疗法药物系统中的抗抑郁药具有副作用。尚未有研究比较过同种疗法和阿育吠陀药物治疗抑郁症的功效和副作用。目的：本研究的目的是通过阿育吠陀制剂来比较丙咪嗪和舍曲林的疗效和副作用，丙咪嗪和舍曲林是用于治疗抑郁症的变态反应药物系统中常用的药物。设置和设计：这项研究是一项开放标签的随机临床试验，涉及90名抑郁症患者，将他们分为三组，每组30名，分别使用丙咪嗪，舍曲林和阿育吠陀制剂。进行HAM-D评分并准备副作用清单。材料和方法：阿育吠陀制剂由Brahmi，Shankhpuship，Malkangni和Jatamansi的水提取物等比例混合而成（每种250 mg）。阿育吠陀制剂以1000毫克的剂量分两次口服;每天以150 mg的剂量服用imipramine和sertraline来分开患者组。随机选择符合纳入和排除标准的人员。以连续两周为间隔的三个月重复评估治疗对受治疗患者的效果。结果：阿育吠陀制剂的副作用可忽略不计，并且发现在三个月末与阿米帕明和舍曲林相当。结论：阿育吠陀制剂因其副作用较小，与丙咪嗪和舍曲林相比，治疗轻至中度抑郁症疗效更好。

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