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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy)
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Predictive Value of Serum Sialic Acid in Type-2 Diabetes Mellitus and Its Complication (Nephropathy)

机译：血清唾液酸在2型糖尿病及其并发症（肾病）中的预测价值

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Introduction: Sialic acid levels are increased in type-2 diabetes mellitus and its estimation helps in predicting the occurrence of microvascular complication such as diabetic nephropathy. The present study compared the levels of sialic acid, glycated haemoglobin, serum creatinine and urine microalbumin: in type-2 diabetics without any complications; in type-2 diabetics with nephropathy; and in age and sex matched healthy individual (controls).Results: The study observed an increased level of sialic acid in type-2 diabetics without any complications and type-2 diabetics with nephropathy. Serum sialic acid levels in type-2 diabetics without any complications was 64.44 ± 3.93 mg/dl, in type-2 diabetics with nephropathy was 73.88 ± 4.41 mg/dl, and in controls it was 53.16 ± 3.40 mg/dl. Urine sialic acid levels in type-2 diabetics without any complications was 6.62 ± 0.70 mg/dl, in type-2 diabetics with nephropathy was 8.46 ± 0.97 mg/dl, and in controls it was 4.44 ± 0.62 mg/dl. Correlation of sialic acid levels with glycated haemoglobin and urine microalbumin was statistically significant but with serum creatinine was not statistically significant.Conclusion: Sialic acid is an important component of vascular cell membrane. Their increased levels indicate extensive vascular damage in type-2 DM. Therefore, estimation of sialic acid levels help in early prediction and prevention of microvascular complications occurring due to diabetics, thereby decreasing the mortality and morbidity in them.
机译：简介：2型糖尿病患者的唾液酸水平升高，其估计有助于预测微血管并发症（如糖尿病性肾病）的发生。本研究比较了2型糖尿病患者中唾液酸，糖化血红蛋白，血清肌酐和尿液微量白蛋白的水平。 2型糖尿病肾病患者;结果：该研究发现无并发症的2型糖尿病患者和2型糖尿病合并肾病患者的唾液酸水平升高。没有任何并发​​症的2型糖尿病患者的血清唾液酸水平为64.44±3.93 mg / dl，患有肾病的2型糖尿病患者的血清唾液酸水平为73.88±4.41 mg / dl，而对照组为53.16±3.40 mg / dl。没有任何并发​​症的2型糖尿病患者的尿唾液酸水平为6.62±0.70 mg / dl，患有肾病的2型糖尿病患者的尿唾液酸水平为8.46±0.97 mg / dl，而对照组为4.44±0.62 mg / dl。唾液酸水平与糖化血红蛋白和尿微量白蛋白的相关性具有统计学意义，而与血清肌酐的相关性则无统计学意义。结论：唾液酸是血管细胞膜的重要组成部分。它们升高的水平表明2型DM中广泛的血管损伤。因此，估计唾液酸水平有助于早期预测和预防由于糖尿病引起的微血管并发症，从而降低它们的死亡率和发病率。

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