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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management
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Acinetobacter baumannii: A Brief Account of Mechanisms of Multidrug Resistance and Current and Future Therapeutic Management

机译：鲍曼不动杆菌：多重耐药机制和当前和未来的治疗管理的简要说明

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摘要

Acinetobacter baumannii, a non-motile, glucose non fermentative, oxidase negative, encapsulated, gram-negative coccobacillus, has recently gained importance because of its increasing resistance to the available antibiotics. Three main mechanisms of resistance in A. baumannii are: enzymes inactivating antibiotics, reduced entry into the target site of bacteria and alteration of the target or cellular functions due to mutations. Multi-drug resistant A. Baumannii, including carbapenam resistant A. Baumannii, are posing a potential threat to mankind by causing lethal infections, especially in ICU set up and in patients who are on ventilators, for which our conventional antibiotics were not shown to be effective. Many reports have indicated carbapenam resistance among A. Baumannii and only colistin and tigecyclyne have shown some promise in combating this lethal microorganism.
机译：鲍曼不动杆菌是一种不运动的，葡萄糖非发酵性的，氧化酶阴性的，包囊的，革兰氏阴性的球菌，由于其对可用抗生素的抗性增强，因此最近变得越来越重要。鲍曼不动杆菌的三种主要耐药机制是：使抗生素失活的酶，减少细菌进入靶标部位的进入以及由于突变而引起的靶标或细胞功能的改变。多重耐药性鲍曼不动杆菌，包括对碳青霉烯耐药的鲍曼不动杆菌，通过致死性感染对人类构成潜在威胁，尤其是在ICU以及呼吸机患者中，我们的常规抗生素并未显示出这种致死性。有效。许多报道表明鲍曼不动杆菌对碳青霉烯有抗药性，只有粘菌素和替加环炔在对抗这种致死微生物方面显示出一定的希望。

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