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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Microbial Profile of Early and Late Onset Ventilator Associated Pneumonia in The Intensive Care Unit of A Tertiary Care Hospital in Bangalore, India
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Microbial Profile of Early and Late Onset Ventilator Associated Pneumonia in The Intensive Care Unit of A Tertiary Care Hospital in Bangalore, India

机译：印度班加罗尔三级护理医院重症监护病房早期和晚期呼吸机相关性肺炎的微生物谱

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Introduction: Ventilator-associated pneumonia (VAP), an important form of hospital-acquired pneumonia (HAP), specifically refers to pneumonia developing in a patient on mechanical ventilator for more than 48 h after intubation or tracheostomy. Despite the advancements in antimicrobial regimes, VAP continues to be an important cause of morbidity and mortality. VAP requires a rapid diagnosis and initiation of appropriate antibiotic treatment, as there is adverse effect of inadequate antibiotic treatment on patients? prognosis and the emergence of multidrug-resistant (MDR) pathogens.Aims: The present study was undertaken to assess the etiological agents of early-onset and late-onset VAP and to know their sensitivity pattern. Material and Methods: VAP data over a period of 12 months (February 2012 -February 2013) in a tertiary care ICU was retrospectively analysed. The patients were stratified by age, sex, duration of VAP (Early/Late onset) and the identified pathogens with their sensitivity pattern.Results: Incidence of VAP was found to be 35.14%, out of which 44.23% had early-onset (4 days MV) VAP. The most common organisms isolated in early onset and late onset VAP was Pseudomonas aeruginosa, E.coli and Acinetobacter baumanii. All enterobacteriaceal isolates were extended spectrum beta lactamase (ESBL) producing organisms and all Staphylococcus aureus isolates except one were methicillin resistant. The incidence of Multidrug resistant (MDR) Pseudomonas aeruginosa and Acinetobacter were 40% and 37.5% respectively.Conclusion: Due to the increasing incidence of multidrug-resistant organisms in our ICU, early and correct diagnosis of VAP is an urgent challenge for an optimal antibiotic treatment and cure. Hence, knowing the local microbial flora causing VAP and effective infection control practices are essential to improve clinical outcomes.
机译：简介：呼吸机相关性肺炎（VAP）是医院获得性肺炎（HAP）的一种重要形式，具体指的是在插管或气管切开术后使用机械呼吸机的患者中发生肺炎的时间超过48小时。尽管抗菌治疗方法有所进步，但VAP仍然是发病率和死亡率的重要原因。 VAP需要快速诊断并开始适当的抗生素治疗，因为抗生素治疗不足会对患者产生不良影响吗？目的：本研究旨在评估早期和晚期VAP的病因，并了解其敏感性模式。资料和方法：回顾性分析三级监护病房中12个月（2012年2月至2013年2月）的VAP数据。按年龄，性别，VAP持续时间（早/晚发作）和病原体及其敏感模式对患者进行分层。结果：VAP发生率为35.14％，其中44.23％为早发。 （4天MV）VAP。在VAP发作早期和发作后期分离的最常见生物是铜绿假单胞菌，大肠杆菌和鲍曼不动杆菌。所有肠杆菌科分离株均为产生​​超广谱β内酰胺酶（ESBL）的生物，除一种耐药菌外，所有金黄色葡萄球菌分离株均耐甲氧西林。铜绿假单胞菌和不动杆菌的多重耐药性分别为40％和37.5％。最佳抗生素治疗和治愈。因此，了解引起VAP的局部微生物菌群和有效的感染控制措施对于改善临床结果至关重要。

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