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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Dermatoglyphics and Karyotype Analysis in Primary Amenorrhoea
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Dermatoglyphics and Karyotype Analysis in Primary Amenorrhoea

机译：原发性闭经的皮肤形态学和核型分析

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Background: Dermatoglyphics is the scientific study of the skin ridge patterns on the fingers, toes, palms of the hands and soles of feet. Dermatoglyphics is in use as a supportive diagnostic tool in genetic or chromosomal disorders as well as in clinical conditions with genetic etiologies. Primary amenorrhoea and Dermatoglyphics, both have the suspected multifactorial (genetic and environmental) aetiologies. Objective: In the present study the finger dermatoglyphic patterns were studied in primary amenorrhoea cases and age matched fertile control females and also attention was given to find out whether a specific dermatoglyphic trait exists in primary amenorrhoea cases and whether it was statistically significant. Materials and Methods: To study the role of dermatoglyphics in primary amenorrhoea, a study was conducted on 30 subjects with primary amenorrhoea (as cases) and compared it with equal number of age matched fertile females (as controls). We studied fingertip patterns in all the subjects enrolled. Simultaneously we have assessed the Karyotype of primary amenorrhoea cases. Result and Conclusion: Two subjects in experimental group have shown abnormal Karyotypes. The most significant finding in present study was increased total finger ridge count (TFRC) in primary amenorrhoea cases which was statistically significant. We also found higher frequency of loops and arches in primary amenorrhoea with abnormal karyotypes. This type of study may be quite useful as a supportive investigation, in stating the predisposition of an individual to primary amenorrhoea and referral of an individual for karyotyping.
机译：背景：皮肤象形文字是对手指，脚趾，手掌和脚底上的皮肤纹的科学研究。皮肤文字学被用作遗传或染色体疾病以及遗传病因的临床疾病中的辅助诊断工具。原发性闭经和皮纹症都有可疑的多因素（遗传和环境）病因。目的：在本研究中，研究了原发性闭经和年龄匹配的可育对照女性的手指皮纹特征，并关注发现原发性闭经患者是否存在特定的皮纹特征及其统计意义。资料和方法：为了研究皮肤象形文字在原发性闭经中的作用，对30名原发性闭经的受试者（视情况而定）进行了一项研究，并将其与相等年龄匹配的可育女性（作为对照）进行了比较。我们研究了所有受试者的指尖模式。同时，我们评估了原发性闭经病例的核型。结果与结论：实验组中有两名受试者表现出异常的核型。在本研究中，最重要的发现是原发性闭经病例的总手指计数（TFRC）增加，这在统计学上是有意义的。我们还发现具有异常核型的原发性闭经中higher和弓的发生频率更高。这种类型的研究作为支持性研究可能非常有用，它可以说明个体易患原发性闭经和将个体转诊为染色体核型分析。

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