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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Propofol and Ketamine versus Propofol and Fentanyl for Puerperal Sterilization, A Randomized Clinical Trial
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Comparison of Propofol and Ketamine versus Propofol and Fentanyl for Puerperal Sterilization, A Randomized Clinical Trial

机译：异丙酚和氯胺酮与丙泊酚和芬太尼用于产后绝育的比较，一项随机临床试验

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Background: Puerperal sterilization requires a rapid recovery of the mother so that she can take care of her child. Propofol with fentanyl (PF) is an option, but is associated with intraoperative hypotension, respiratory depression and an unsatisfactory postoperative recovery profile. Propofol with ketamine (PK) appears to be an alternative in terms of haemodynamic stability and analgesia. Materials and Methods: This randomized clinical trial involved 60 patients who were scheduled to undergo puerperal sterilization, who belonged to American society of anaesthesiologists (ASA) physical status 1. Patients were randomly allocated to receive either ketamine ? propofol infusion in a concentration of 8mg/ml each (group PK) or fentanyl 2μg/kg intravenously, followed by an infusion of propofol in a concentration of 8mg/ml (group PF). In both the groups, the infusion was started at 300ml/hr till patient lost consciousness. Subsequently, the rate was set at 1.5ml/ kg/hr for group PF and at 0.75ml/kg/hr for group PK. After the initial 10 minutes, the infusion rate was reduced to 1ml/kg/hr for group PF and to 0.5ml/kg/hr for group PK. Blood pressure and saturation were the primary outcomes which were measured.Results: Patients from group PF recorded a significant drop in the systolic blood pressure from the 5th minute, in diastolic pressure from the 10th minute and transient oxygen desaturation, as compared to group PK. Patients in group PK had adequate surgical conditions and better recovery profiles in terms of pain and sedation.Conclusion: The combination of ketamine and propofol is a safe and possibly superior alternative to propofol ? fentanyl combination in patients who undergo puerperal sterilization, in terms of haemodynamic stability and respiratory depression.
机译：背景：产后绝育需要母亲的快速康复，以便她可以照顾孩子。异丙酚联合芬太尼（PF）是一种选择，但与术中低血压，呼吸抑制和术后恢复情况不理想有关。就血流动力学稳定性和镇痛而言，异丙酚与氯胺酮（PK）似乎是一种替代选择。资料和方法：这项随机临床试验包括60名计划接受产褥期绝育的患者，这些患者属于美国麻醉医师协会（ASA）身体状况1。分别以8mg / ml的浓度输注丙泊酚（PK组）或静脉注射芬太尼2μg/ kg，然后以8mg / ml的浓度输注丙泊酚（PF组）。两组患者均以300ml / hr的速度开始输注直至患者失去知觉。随后，对于PF组，速率设置为1.5ml / kg / hr，对于PK组，速率设置为0.75ml / kg / hr。在最初的10分钟后，PF组的输注速度降至1ml / kg / hr，PK组的输注速度降至0.5ml / kg / hr。结果：测量的主要结果是血压和饱和度。结果：与PK组相比，PF组的患者从第5分钟开始的收缩压显着下降，从第10分钟开始的舒张压和短暂的氧饱和度显着下降。 PK组患者的手术条件适当，并且在疼痛和镇静方面具有更好的恢复。结论：氯胺酮和丙泊酚的组合是一种安全且可能优于丙泊酚的替代品？从血液动力学稳定性和呼吸抑制方面考虑，芬太尼组合在产褥期绝育患者中的作用。

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