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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Topical Anti- Fungal Agents Sertaconazole and Clotrimazole in the Treatment of Tinea Corporis-An Observational Study
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Comparison of Topical Anti- Fungal Agents Sertaconazole and Clotrimazole in the Treatment of Tinea Corporis-An Observational Study

机译：局部抗真菌药舍他康唑和克霉唑治疗皮肤癣的比较-观察性研究

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Objectives: To compare the efficacy of topical antifungal agents, Sertaconazole and Clotrimazole in Tinea corporis patients. Materials and Methods: A total of 60(n=60) patients were included in the study. They were divided into two groups of 30 patients each. First group included patients treated with topical Sertaconazole as test drug whereas the second group constituted patients treated with topical Clotrimazole as standard drug. The patients were advised to apply the drug on affected area twice daily for three weeks. The parameters like erythema, scaling, itching, margins and size of the lesion and KOH mount were taken for the assessment of efficacy. This was an open labelled study and patients were followed up every week for three weeks. Results: The total score included all grades in erythema, itching, scaling, margins and size of lesion and KOH mount. There was significant reduction in erythema (p<0.02) and highly significant reduction in scaling (p<0.001), itching (p<0.001) and margins of lesion (p<0.001) among Sertaconazole group. The mean difference and the standard deviation of total scores for Clotrimazole were 7.20 and 1.69 and for Sertaconazole group 8.80 and 1.52 respectively. The p-value on application of students unpaired t- test was p<0.001 (Highly significant). Conclusion: From the present study, it can be concluded that topical Sertaconazole shows better improvement in the clinical parameters than topical Clotrimazole within a span of three weeks in the treatment of T corporis.
机译：目的：比较局部抗真菌药，舍他康唑和克霉唑对体癣的疗效。材料和方法：总共60名患者（n = 60）被纳入研究。他们分为两组，每组30名患者。第一组包括局部用舍他康唑治疗的患者，第二组包括局部用克霉唑治疗的患者。建议患者每天两次在患处上药，持续3周。评估红斑，鳞屑，瘙痒，病变的边缘和大小以及KOH坐骨等参数用于评估疗效。这是一项公开标记的研究，患者每周接受随访，为期三周。结果：总分包括红斑，瘙痒，鳞屑，病变的边缘和大小以及KOH坐骑的所有等级。 Sertaconazole组的红斑显着减少（p <0.02），结垢（p <0.001），瘙痒（p <0.001）和病变边缘（p <0.001）显着减少。克霉唑的平均差异和总分的标准差分别为7.20和1.69，而舍他康唑组分别为8.80和1.52。应用未配对t检验的学生的p值为p <0.001（高度显着）。结论：从本研究中可以得出结论，在三周内治疗T corporis的过程中，局部用舒他康唑比局部用克霉唑在临床指标上有更好的改善。

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