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首页> 外文期刊>Journal of Clinical and Diagnostic Research >Comparison of Serum Lipid Profile in HIV Positive Patientson ART with ART Na?ve Patients
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Comparison of Serum Lipid Profile in HIV Positive Patientson ART with ART Na?ve Patients

机译：HIV阳性患者和ART初治患者血清脂质谱的比较

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Introduction: The widespread use of effective highly active antiretroviral therapy (HAART) in HIV patients has coincided with increasing reports of complications like HIV-associated lipodystrophy syndrome and the metabolic alterations, affecting the lipid and glucose metabolism. Evidences in support of lipodystrophy and dyslipidaemia associated with First- line HAART in our area is scarce. The aim of the present study was 1) to study and compare Lipid profile in HIV positive patients on ART with that of freshly diagnosed HIV positive patients who were yet to be started on ART. 2) To assess lipodystrophy syndrome in patients on ART.Materials and Methods: Hundred newly diagnosed HIV positive patients who were yet to be started on ART were taken as controls (ART-Na?ve).Hundred randomly selected HIV+ patients who were already on First-line ART regimen (Stavudine/Zudovudine + Lamivudine + Nevirapine) for more than 12 months were taken as cases (ART). This study was conducted for a period of 12 months at the VIMS ART centre, Bellary.Results: There was a significant increase (p<0.001) in serum Total Cholesterol, LDL-C, TG, VLDL, Non-HDL -C & TC/HDL-C ratio in ART patients compared to ART-na?ve patients. Of the 100 ART patients 23 had lipodystrophy syndrome (buffalo hump, abnormal fat deposition around neck & back, buccal fat resorption, increase in abdominal fat).Conclusion: To conclude, it is evident from our study that there is increase in lipid profile (except HDL) in ART patients compared to ART Na?ve group and twenty three ART patients showed lipodystrophy syndrome. Hence it appears reasonable to measure fasting lipid levels before and 3-6 months after antiretroviral therapy is initiated or when ART regimen is changed.
机译：简介：在艾滋病毒患者中广泛使用有效的高效抗逆转录病毒疗法（HAART）的同时，也出现了越来越多的并发症报告，例如与HIV相关的脂肪营养不良综合征和代谢改变，从而影响脂质和葡萄糖的代谢。在我们地区，缺乏与一线HAART相关的脂肪营养不良和血脂异常的证据。本研究的目的是1）研究和比较接受ART治疗的HIV阳性患者与尚未开始接受ART的新诊断HIV阳性患者的血脂谱。 2）通过ART评估患者的脂肪营养不良综合征。材料与方法：选取刚开始接受ART治疗的数百名新诊断出的HIV阳性患者作为对照（ART-Nave），随机选择了数百名已接受HIV +的患者。一线抗逆转录病毒疗法（司他夫定/祖多夫定+拉米夫定+奈韦拉平）治疗时间超过12个月（ART）。这项研究在Bellary的VIMS ART中心进行了为期12个月的研究。结果：血清总胆固醇，LDL-C，TG，VLDL，Non-HDL -C和TC显着增加（p <0.001）与未接受过ART治疗的患者相比，ART患者的/ HDL-C比率。在100名ART患者中，有23名患有脂肪营养不良综合征（水牛驼峰，脖子和背部的脂肪沉积异常，颊脂吸收，腹部脂肪增加）。结论：总而言之，从我们的研究中可以明显看出，脂质分布增加（ ART朴素组和ART朴素组相比，除HDL外）和23例ART患者表现出脂肪营养不良综合征。因此，在开始抗逆转录病毒治疗之前或之后或改变ART方案时，测量空腹血脂水平似乎是合理的。

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