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Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae

机译:广谱β-内酰胺酶产生肺炎克雷伯菌引起的新生儿脑脓肿

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Klebsiella pneumoniae (K. pneumoniae) causing brain abscess in newborn infants is rare. Presented herein, is a 27-day-old male neonate who developed two frontal lobe abscesses in association with K. pneumoniae sepsis and meningitis. Antibiotic susceptibility testing utilizing the double-disk synergy method (Cefotaxime and Amoxycillin-Clavulanate) confirmed the extended spectrum beta-lactamase (ESBL) production by the isolate. He was treated simultaneously with antibiotics (Meropenem and Amikacin) and abscess aspiration through the anterior fontanelle, with less than satisfactory outcome. ESBL producing K. pneumoniae brain abscess in neonates is extremely rare in the English literature. Emperical carbapenems and aminoglycoside coverage in neonates with K. pneumoniae sepsis and brain abscess, especially in areas with high rate of ESBL producing bacteria may be warranted
机译:引起新生儿脑脓肿的肺炎克雷伯菌(K. pneumoniae)很少。本文介绍的是一名27天大的男性新生儿,其与肺炎克雷伯氏菌败血症和脑膜炎有关,出现了两个额叶脓肿。使用双盘协同方法(头孢噻肟和阿莫西林-克拉维酸盐)的抗生素药敏试验证实了分离株产生的广谱β-内酰胺酶(ESBL)。他同时接受了抗生素(美罗培南和丁胺卡那霉素)治疗,并通过前font部脓肿抽吸,效果不理想。 ESBL在新生儿中产生肺炎克雷伯菌脑脓肿在英语文献中极为罕见。肺炎克雷伯氏菌败血症和脑脓肿的新生儿,尤其是在ESBL产生菌率高的地区,应有天然碳青霉烯类和氨基糖苷类覆盖

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